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Science 3 June 1983:
Vol. 220. no. 4601, pp. 1071 - 1072
DOI: 10.1126/science.6133353
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Articles

Science, Vol 220, Issue 4601, 1071-1072
Copyright © 1983 by American Association for the Advancement of Science

articles

Adrenocorticotropic hormone causes long-lasting potentiation of transmitter release from frog motor nerve terminals

MF Johnston, EA Kravitz, H Meiri, and R Rahamimoff

Exposure of frog neuromuscular preparations to adrenocorticotropic hormone for several minutes increased both nerve-evoked and spontaneous transmitter release for several hours. No changes in postsynaptic sensitivity to transmitter were detected. The long-lasting potentiation shows little sensitivity to changes in extracellular calcium concentration and seems to be entirely presynaptic in origin.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)