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Science 3 June 1983:
Vol. 220. no. 4601, pp. 1055 - 1057
DOI: 10.1126/science.6844925
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Articles

Science, Vol 220, Issue 4601, 1055-1057
Copyright © 1983 by American Association for the Advancement of Science

articles

DNA methylation decreases in aging but not in immortal cells

VL Wilson and PA Jones

When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.


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