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Science 27 May 1983:
Vol. 220. no. 4600, pp. 955 - 956
DOI: 10.1126/science.6302839
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Articles

Science, Vol 220, Issue 4600, 955-956
Copyright © 1983 by American Association for the Advancement of Science

articles

Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene

A Eva and SA Aaronson

The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This transforming gene was identified as the activated homolog of the Kirsten murine sarcoma virus onc gene, v-kis. The finding that a defined carcinogen reproducibly leads to activation of kis as a transforming gene should be of value in elucidating the role of oncogenes in the neoplastic process.


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A transforming ras gene in tumorigenic guinea pig cell lines initiated by diverse chemical carcinogens.
S Sukumar, S Pulciani, J Doniger, J. DiPaolo, C. Evans, B Zbar, and M Barbacid (1984)
Science 223, 1197-1199
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