Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 May 1983:
Vol. 220. no. 4600, pp. 949 - 951
DOI: 10.1126/science.220.4600.949
Prev | Table of Contents | Next

Articles

Total Synthesis of the L-Hexoses

SOO Y. KO 1, ALBERT W. M. LEE 1, SATORU MASAMUNE 1, LAWRENCE A. REED III 1, K. BARRY SHARPLESS 1, and FREDERICK J. WALKER 1

1 Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139

Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

Submitted on November 8, 1982


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Two-Step Synthesis of Carbohydrates by Selective Aldol Reactions.
A. B. Northrup and D. W. C. MacMillan (2004)
Science 305, 1752-1755
   Abstract »    Full Text »    PDF »
Asymmetric Catalysis Special Feature Part I: Asymmetric catalysis in complex target synthesis.
M. S. Taylor and E. N. Jacobsen (2004)
PNAS 101, 5368-5373
   Abstract »    Full Text »    PDF »
Current Status of Asymmetric Synthesis.
H. S. Mosher and J. D. Morrison (1983)
Science 221, 1013-1019
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)