Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 May 1983:
Vol. 220. no. 4600, pp. 924 - 928
DOI: 10.1126/science.6189184
Prev | Table of Contents | Next

Articles

Science, Vol 220, Issue 4600, 924-928
Copyright © 1983 by American Association for the Advancement of Science

articles

Genetic expression in the developing brain

N Chaudhari and WE Hahn

The adult mouse brain contains complex populations of polyadenylated [poly(A)+] and nonpolyadenylated [poly(A)-] messenger RNA's (mRNA's). These mRNA's are separate sequence populations, similar in complexity, and in combination are equivalent to approximately 150,000 different mRNA sequences, of average length. Essentially all of the "adult" poly(A)+ mRNA's are present in the brain at birth. In contrast, most of the poly(A)- mRNA's are absent. Brain poly(A)- mRNA's begin to appear soon after birth, but the full adult complement is not reached until young adulthood. This suggests that these poly(A)- mRNA's specify proteins required for the biological capabilities of the brain that emerge during the course of postnatal development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mice, microarrays, and the genetic diversity of the brain.
D. H. Geschwind (2000)
PNAS 97, 10676-10678
   Full Text »    PDF »
In situ transcription: specific synthesis of complementary DNA in fixed tissue sections.
L. Tecott, J. Barchas, and J. Eberwine (1988)
Science 240, 1661-1664
   Abstract »    PDF »
Plants: novel developmental processes.
R. Goldberg (1988)
Science 240, 1460-1467
   Abstract »    PDF »
A Mab to a unique cerebellar neuron generated by immunosuppression and rapid immunization.
S Hockfield (1987)
Science 237, 67-70
   Abstract »    PDF »
Control of neuronal gene expression.
J. Sutcliffe, R. Milner, J. Gottesfeld, and W Reynolds (1984)
Science 225, 1308-1315
   Abstract »    PDF »
Replication timing of genes and middle repetitive sequences.
M. Goldman, G. Holmquist, M. Gray, L. Caston, and A Nag (1984)
Science 224, 686-692
   Abstract »    PDF »
Genetic Expression and Postnatal Development of the Brain: Some Characteristics of Nonpolyadenylated mRNAs.
W.E. Hahn, N. Chaudhari, L. Beck, K. Wilber, and D. Peffley (1983)
Cold Spring Harb Symp Quant Biol 48, 465-475
   Abstract »    PDF »
Gene Expression and the Diversity of Identified Neurons.
L. Buck, R. Stein, M. Palazzolo, D.J. Anderson, and R. Axel (1983)
Cold Spring Harb Symp Quant Biol 48, 485-492
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)