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Science 20 May 1983:
Vol. 220. no. 4599, pp. 868 - 871
DOI: 10.1126/science.6189183
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Articles

Science, Vol 220, Issue 4599, 868-871
Copyright © 1983 by American Association for the Advancement of Science

articles

Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)

F Barre-Sinoussi, JC Chermann, F Rey, MT Nugeyre, S Chamaret, J Gruest, C Dauguet, C Axler-Blin, F Vezinet-Brun, C Rouzioux, W Rozenbaum, and L Montagnier

A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this patient react with proteins from viruses of the HTLV-I subgroup, but type-specific antisera to HTLV-I do not precipitate proteins of the new isolate. The virus from this patient has been transmitted into cord blood lymphocytes, and the virus produced by these cells is similar to the original isolate. From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.


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AIDS -- Past and Future.
M. S. Gottlieb (2001)
N. Engl. J. Med. 344, 1788-1791
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Envelope Glycoprotein Determinants of Neutralization Resistance in a Simian-Human Immunodeficiency Virus (SHIV-HXBc2P 3.2) Derived by Passage in Monkeys.
Z. Si, M. Cayabyab, and J. Sodroski (2001)
J. Virol. 75, 4208-4218
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Loss of a Single N-Linked Glycan Allows CD4-Independent Human Immunodeficiency Virus Type 1 Infection by Altering the Position of the gp120 V1/V2 Variable Loops.
P. Kolchinsky, E. Kiprilov, P. Bartley, R. Rubinstein, and J. Sodroski (2001)
J. Virol. 75, 3435-3443
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Increased Neutralization Sensitivity of CD4-Independent Human Immunodeficiency Virus Variants.
P. Kolchinsky, E. Kiprilov, and J. Sodroski (2001)
J. Virol. 75, 2041-2050
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GLI-2 Modulates Retroviral Gene Expression.
M. J. Smith, S. D. Gitlin, C. M. Browning, B. R. Lane, N. M. Clark, N. Shah, S. Rainier, and D. M. Markovitz (2001)
J. Virol. 75, 2301-2313
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A human myeloma cell line suitable for the generation of human monoclonal antibodies.
A. Karpas, A. Dremucheva, and B. H. Czepulkowski (2001)
PNAS 98, 1799-1804
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Apelin, the Natural Ligand of the Orphan Seven-Transmembrane Receptor APJ, Inhibits Human Immunodeficiency Virus Type 1 Entry.
M. Cayabyab, S. Hinuma, M. Farzan, H. Choe, S. Fukusumi, C. Kitada, N. Nishizawa, M. Hosoya, O. Nishimura, T. Messele, et al. (2000)
J. Virol. 74, 11972-11976
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Tat Protein Is an HIV-1-Encoded {beta}-Chemokine Homolog That Promotes Migration and Up-Regulates CCR3 Expression on Human Fc{epsilon}RI+ Cells.
A. de Paulis, R. De Palma, L. Di Gioia, M. Carfora, N. Prevete, G. Tosi, R. S. Accolla, and G. Marone (2000)
J. Immunol. 165, 7171-7179
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Introduction: Therapeutic Issues in the Management of Patients Infected with the Human Immunodeficiency Virus (HIV).
J. M. Brocavich, J. V. Etzel, and T. J. Kanmaz (2000)
Journal of Pharmacy Practice 13, 422-425
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The Level of CD4 Expression Limits Infection of Primary Rhesus Monkey Macrophages by a T-Tropic Simian Immunodeficiency Virus and Macrophagetropic Human Immunodeficiency Viruses.
N. Bannert, D. Schenten, S. Craig, and J. Sodroski (2000)
J. Virol. 74, 10984-10993
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Importance of Membrane Fusion Mediated by Human Immunodeficiency Virus Envelope Glycoproteins for Lysis of Primary CD4-Positive T Cells.
J. A. LaBonte, T. Patel, W. Hofmann, and J. Sodroski (2000)
J. Virol. 74, 10690-10698
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