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Science 13 May 1983:
Vol. 220. no. 4598, pp. 733 - 735
DOI: 10.1126/science.6836311
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Articles

Science, Vol 220, Issue 4598, 733-735
Copyright © 1983 by American Association for the Advancement of Science

articles

Social stress and atherosclerosis in normocholesterolemic monkeys

Kaplan JR, SB Manuck, TB Clarkson, FM Lusso, DM Taub, and EW Miller

Socially stressed adult male cynomolgus monkeys (Macaca fascicularis) fed a low fat, low cholesterol diet developed more extensive coronary artery atherosclerosis than unstressed controls. Groups did not differ in serum lipids, blood pressure, serum glucose, or ponderosity. These results suggest that psychosocial factors may influence atherogenesis in the absence of elevated serum lipids. Psychosocial factors thus may help explain the presence of coronary artery disease (occasionally severe) in people with low or normal serum lipids and normal values for the other "traditional" risk factors.


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