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Science 13 May 1983:
Vol. 220. no. 4598, pp. 680 - 686
DOI: 10.1126/science.6403986
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Articles

Science, Vol 220, Issue 4598, 680-686
Copyright © 1983 by American Association for the Advancement of Science

articles

Bone cell differentiation and growth factors

MR Urist, RJ DeLange, and GA Finerman

Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.


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