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Science 29 April 1983:
Vol. 220. no. 4596, pp. 524 - 527
DOI: 10.1126/science.6836297
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Articles

Science, Vol 220, Issue 4596, 524-527
Copyright © 1983 by American Association for the Advancement of Science

articles

Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation

RR Anderson and JA Parrish

Suitably brief pulses of selectively absorbed optical radiation can cause selective damage to pigmented structures, cells, and organelles in vivo. Precise aiming is unnecessary in this unique form of radiation injury because inherent optical and thermal properties provide target selectivity. A simple, predictive model is presented. Selective damage to cutaneous microvessels and to melanosomes within melanocytes is shown after 577-nanometer (3 x 10(-7) second) and 351-nanometer (2 x 10(-8) second) pulses, respectively. Hemodynamic, histological, and ultrastructural responses are discussed.


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Pigmented Guinea Pig Skin Irradiated With Q-Switched Ruby Laser Pulses: Morphologic and Histologic Findings.
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The Treatment of Port-wine Stains by the Pulsed Dye Laser: Analysis of Pulse Duration and Long-term Therapy.
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Arch Dermatol 124, 889-896
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Amelioration of Experimental Lipid Keratopathy by Photochemically Induced Thrombosis of Feeder Vessels.
A. D. Mendelsohn, B. D. Watson, E. C. Alfonso, M. Lieb, G. P. Mendelsohn, R. K. Forster, and J. J. Dennis (1987)
Arch Ophthalmol 105, 983-988
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Carbon Dioxide Lasers: A Broader Perspective.
R. R. Anderson (1987)
Arch Dermatol 123, 566-567
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Histologic Responses of Port-wine Stains Treated by Argon, Carbon Dioxide, and Tunable Dye Lasers: A Preliminary Report.
O. T. Tan, J. M. Carney, R. Margolis, Y. Seki, J. Boll, R. R. Anderson, and J. A. Parrish (1986)
Arch Dermatol 122, 1016-1022
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Laser-induced alteration of collagen substructure allows microsurgical tissue welding.
R Schober, F Ulrich, T Sander, H Durselen, and S Hessel (1986)
Science 232, 1421-1422
   Abstract »    PDF »


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