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Science 29 April 1983:
Vol. 220. no. 4596, pp. 519 - 521
DOI: 10.1126/science.6132446
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Articles

Science, Vol 220, Issue 4596, 519-521
Copyright © 1983 by American Association for the Advancement of Science

articles

Vasoactive intestinal polypeptide and muscarinic receptors: supersensitivity induced by long-term atropine treatment

B Hedlund, J Abens, and T Bartfai

Long-term treatment of rats with atropine induced large increases in the numbers of muscarinic receptors and receptors for vasoactive intestinal polypeptide in the salivary glands. Since receptors for vasoactive intestinal polypeptide coexist with muscarinic receptors on the same neurons in this preparation, the results suggest that a drug that alters the sensitivity of one receptor may also affect the sensitivity of the receptor for a costored transmitter and in this way contribute to the therapeutic or side effects of the drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Effect of Chronic Atropine Treatment on Salivary Composition and Caries in Rats.
G.E. Watson, S.K. Pearson, J.L. Falany, D.J. Culp, L.A. Tabak, and W.H. Bowen (1989)
Journal of Dental Research 68, 1739-1745
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