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Science 29 April 1983:
Vol. 220. no. 4596, pp. 502 - 505
DOI: 10.1126/science.6836294
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Articles

Science, Vol 220, Issue 4596, 502-505
Copyright © 1983 by American Association for the Advancement of Science

articles

Liposomal blockade of the reticuloendothelial system: improved tumor imaging with small unilamellar vesicles

RT Proffitt, LE Williams, CA Presant, GW Tin, JA Uliana, RC Gamble, and JD Baldeschwieler

The reticuloendothelial system of mice bearing EMT6 tumors was effectively blocked by intravenous injections of small unilamellar vesicles that incorporated a 6-aminomannose derivative of cholesterol in the lipid bilayer. Neutral liposomes loaded with indium-111-nitrilotriacetic acid were then injected. Fifty percent more radioactivity was deposited in tumors of the animals with blocked reticuloendothelial systems than in controls. Twenty-four hours after the injection of radioactive vesicles, well-defined tumor images were observed in whole-body gamma camera scintigraphs. Biodistribution studies showed that tumors from animals with blocked reticuloendothelial systems had more than twice the radioactivity per gram than any other tissue analyzed.


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