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Science 22 April 1983:
Vol. 220. no. 4595, pp. 423 - 425
DOI: 10.1126/science.6301008
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Articles

Science, Vol 220, Issue 4595, 423-425
Copyright © 1983 by American Association for the Advancement of Science

articles

Serum ferritin as a predictor of host response to hepatitis B virus infection

ED Lustbader, HW Hann, and BS Blumberg

With hemodialysis patients, a high serum ferritin before there was serological evidence of hepatitis B virus infection increased the likelihood that the infection would be persistent. This finding suggested that hepatitis B virus is likely to infect and actively replicate in liver cells with the propensity for increased ferritin synthesis. The virus itself could stimulate the synthesis of ferritin in a cyclic positive feedback mechanism that increases intracellular ferritin concentration and, eventually, intracellular iron. Transformed liver cells have low iron content, do not replicate hepatitis B virus, and require iron for growth. Infected, nonmalignant liver cells could supply iron to the transformed cells and nourish their expansion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Erythrophagocytosis by Liver Macrophages (Kupffer Cells) Promotes Oxidative Stress, Inflammation, and Fibrosis in a Rabbit Model of Steatohepatitis: Implications for the Pathogenesis of Human Nonalcoholic Steatohepatitis.
K. Otogawa, K. Kinoshita, H. Fujii, M. Sakabe, R. Shiga, K. Nakatani, K. Ikeda, Y. Nakajima, Y. Ikura, M. Ueda, et al. (2007)
Am. J. Pathol. 170, 967-980
   Abstract »    Full Text »    PDF »
Hepatocellular Carcinoma and Hepatitis Virus.
R. B. Birrer, D. Birrer, and J. V. Klavins (2003)
Ann. Clin. Lab. Sci. 33, 39-54
   Abstract »    Full Text »    PDF »
Induction of Ferritin Synthesis in Cells Infected with Mengo Virus.
M. R. Mulvey, L. C. Kühn, and D. G. Scraba (1996)
J. Biol. Chem. 271, 9851-9857
   Abstract »    Full Text »    PDF »


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