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Science 22 April 1983:
Vol. 220. no. 4595, pp. 421 - 423
DOI: 10.1126/science.6836284
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Articles

Science, Vol 220, Issue 4595, 421-423
Copyright © 1983 by American Association for the Advancement of Science

articles

Primary murine bone marrow cultures support continuous growth of infectious human trypanosomes

AE Balber

The human parasite Trypanosoma brucei gambiense grew continuously at 37 degrees C in primary cultures of murine bone marrow. Cultured parasites remained virulent for mice. Rapid parasite growth coincided with the appearance of adherent adipocyte-epitheloid cell aggregates that also promoted hematopoiesis. This culture system should permit studies of host cell control of trypanosome proliferation, pathogenic effects of trypanosomes on blood cell development, and the relative trypanocidal and marrow suppressive activities of drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cultivation of Clinically Significant Hemoflagellates.
F. L. Schuster and J. J. Sullivan (2002)
Clin. Microbiol. Rev. 15, 374-389
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Science. ISSN 0036-8075 (print), 1095-9203 (online)