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Science 22 April 1983:
Vol. 220. no. 4595, pp. 415 - 417
DOI: 10.1126/science.6301006
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Articles

Science, Vol 220, Issue 4595, 415-417
Copyright © 1983 by American Association for the Advancement of Science

articles

Neutrophil pseudoplatelets: their discrimination by myeloperoxidase demonstration

JS Hanker and BL Giammara

Neutrophils, especially in acute infection or the myeloid leukemias, may shed platelet-sized particles that can readily be distinguished from true platelets because they contain neutrophil myeloperoxidase. This enzyme, unlike platelet peroxidase, is not inhibited by glutaraldehyde. The myeloperoxidase and acid hydrolase levels and continuous plasma membranes of these cell-like particles suggest that they are functional cellular entities. They further differ from platelets in that they contain nuclear remnants, occur in bacteria-laden pus and inflammatory exudates, are ingested by macrophages, and do not adhere to each other or aggregate. They could be involved in the immune response to pathogens or contribute to trauma and healing by facilitating deployment of neutrophil acid hydrolase, neutral protease, and myeloperoxidase.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Macrophages Acquire Neutrophil Granules for Antimicrobial Activity against Intracellular Pathogens.
B. H. Tan, C. Meinken, M. Bastian, H. Bruns, A. Legaspi, M. T. Ochoa, S. R. Krutzik, B. R. Bloom, T. Ganz, R. L. Modlin, et al. (2006)
J. Immunol. 177, 1864-1871
   Abstract »    Full Text »    PDF »
Pseudoplatelets: a retrospective study of their incidence and interference with platelet counting.
W van der Meer, M A MacKenzie, J W B Dinnissen, and M H de Keijzer (2003)
J. Clin. Pathol. 56, 772-774
   Abstract »    Full Text »    PDF »


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