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Science 15 April 1983:
Vol. 220. no. 4594, pp. 329 - 331
DOI: 10.1126/science.6836277
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Articles

Science, Vol 220, Issue 4594, 329-331
Copyright © 1983 by American Association for the Advancement of Science

articles

Altered activity in the hippocampus is more detrimental to classical conditioning than removing the structure

PR Solomon, SD Solomon, EV Schaaf, and HE Perry

Hippocampal ablation has no effect on the acquisition of the rabbit's classically conditioned nictitating membrane response. Systemic administration of scopolamine, which alters hippocampal neuronal activity, severely retards acquisition of the conditioned response in normal animals and those with cortical ablations. In animals with hippocampal ablations, however, scopolamine has no effect on conditioning. These findings suggest that altered neuronal activity in the hippocampus is more detrimental to conditioning than removing the structure.


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