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Science 15 April 1983:
Vol. 220. no. 4594, pp. 320 - 321
DOI: 10.1126/science.6301004
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Articles

Science, Vol 220, Issue 4594, 320-321
Copyright © 1983 by American Association for the Advancement of Science

articles

Sodium currents in segments of human heart cells

JO Bustamante and TF McDonald

Isolated human heart cells were partially drawn into the lumen of a plastic tube and cleaved at the partitioning tube wall by intraluminal suction pulses. The extraluminal segment (10 to 20 percent of the cell length) was suitable for intracellular perfusion and voltage clamp. The time and voltage dependence of the sodium current, and the responses to changes in driving force and channel blockers, illustrate the potential of these preparations as models for the study of membrane channels.


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Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.
T. Zimmer, C. Bollensdorff, V. Haufe, E. Birch-Hirschfeld, and K. Benndorf (2002)
Am J Physiol Heart Circ Physiol 282, H1007-H1017
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