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Science 15 April 1983:
Vol. 220. no. 4594, pp. 314 - 316
DOI: 10.1126/science.6132444
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Articles

Science, Vol 220, Issue 4594, 314-316
Copyright © 1983 by American Association for the Advancement of Science

articles

Irreversible ligands with high selectivity toward delta and mu opiate receptors

KC Rice, AE Jacobson, TR Burke Jr, BS Bajwa, RA Streaty, and WA Klee

Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Extending the cardioprotective window using a novel {delta}-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway.
E. R. Gross, J. N. Peart, A. K. Hsu, J. A. Auchampach, and G. J. Gross (2005)
Am J Physiol Heart Circ Physiol 288, H2744-H2749
   Abstract »    Full Text »    PDF »
Nitrocinnamoyl and Chlorocinnamoyl Derivatives of Dihydrocodeinone: In Vivo and In Vitro Characterization of µ-Selective Agonist and Antagonist Activity.
J. P. McLaughlin, K. P. Hill, Q. Jiang, A. Sebastian, S. Archer, and J. M. Bidlack (1999)
J. Pharmacol. Exp. Ther. 289, 304-311
   Abstract »    Full Text »
Inhibition of Reinforcing Effects of Morphine and Motivational Aspects of Naloxone-Precipitated Opioid Withdrawal by N-Methyl-D-aspartate Receptor Antagonist, Memantine.
P. Popik and W. Danysz (1997)
J. Pharmacol. Exp. Ther. 280, 854-865
   Abstract »    Full Text »
Irreversible Binding of cis-(+)-3-Methylfentanyl Isothiocyanate to the [IMAGE] Opioid Receptor and Determination of Its Binding Domain.
J. Zhu, J. Yin, P.-Y. Law, P. A. Claude, K. C. Rice, C. J. Evans, C. Chen, L. Yu, and L.-Y. Liu-Chen (1996)
J. Biol. Chem. 271, 1430-1434
   Abstract »    Full Text »    PDF »


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