Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 8 April 1983:
Vol. 220. no. 4593, pp. 218 - 221
DOI: 10.1126/science.6828891
Prev | Table of Contents | Next

Articles

Science, Vol 220, Issue 4593, 218-221
Copyright © 1983 by American Association for the Advancement of Science

articles

Dopamine modulation of the effects of gamma-aminobutyric acid on substantia nigra pars reticulata neurons

BL Waszcak and Walters JR

Studies were conducted to assess whether basal ganglia output neurons originating in the substantia nigra pars reticulata might be affected by dopamine released from dendrites of neighboring substantia nigra pars compacta neurons. Dopamine applied by iontophoresis increased the baseline firing rates of approximately half of the substantia nigra pars reticulata cells tested. The more significant finding, unrelated to the increase in firing, was the ability of dopamine to attenuate the inhibitory responses of these cells to iontophoretically applied gamma-aminobutyric acid. These findings suggest a role for dopamine as a neuromodulator and further suggest that it can act at sites beyond the striatum to modify transmission from the basal ganglia to motor nuclei.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An Ultra-Short Dopamine Pathway Regulates Basal Ganglia Output.
F.-W. Zhou, Y. Jin, S. G. Matta, M. Xu, and F.-M. Zhou (2009)
J. Neurosci. 29, 10424-10435
   Abstract »    Full Text »    PDF »
Activation of Nigral and Pallidal Dopamine D1-Like Receptors Modulates Basal Ganglia Outflow in Monkeys.
M. A. Kliem, N. T. Maidment, L. C. Ackerson, S. Chen, Y. Smith, and T. Wichmann (2007)
J Neurophysiol 98, 1489-1500
   Abstract »    Full Text »    PDF »
Dopamine Gates Action Potential Backpropagation in Midbrain Dopaminergic Neurons.
L. J. Gentet and S. R. Williams (2007)
J. Neurosci. 27, 1892-1901
   Abstract »    Full Text »    PDF »
GABA, Not Glutamate, Controls the Activity of Substantia Nigra Reticulata Neurons in Awake, Unrestrained Rats.
F. Windels and E. A. Kiyatkin (2004)
J. Neurosci. 24, 6751-6754
   Abstract »    Full Text »    PDF »
Regulation of Rat Cortex Function by D1 Dopamine Receptors in the Striatum.
H. Steiner and S. T. Kitai (2000)
J. Neurosci. 20, 5449-5460
   Abstract »    Full Text »    PDF »
gamma -Aminobutyric AcidA Agonists Differentially Augment Gnawing Induced by Indirect-Acting Dopamine Agonists in C57BL/6J Mice.
E. Tirelli, B. Geter-Douglass, and J. M. Witkin (1998)
J. Pharmacol. Exp. Ther. 284, 116-124
   Abstract »    Full Text »
Differential Autoreceptor Control of Somatodendritic and Axon Terminal Dopamine Release in Substantia Nigra, Ventral Tegmental Area, and Striatum.
S. J. Cragg and S. A. Greenfield (1997)
J. Neurosci. 17, 5738-5746
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)