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Science 25 March 1983:
Vol. 219. no. 4591, pp. 1437 - 1438
DOI: 10.1126/science.6681915
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Articles

Science, Vol 219, Issue 4591, 1437-1438
Copyright © 1983 by American Association for the Advancement of Science

articles

Regulation of carcinogen metabolism in the rat ovary by the estrous cycle and gonadotropin

M Bengtsson and J Rydstrom

The activity of 7,12-dimethylbenz[a]anthracene hydroxylase in the rat ovary is several times higher in the proestrous phase of the estrous cycle than in the estrous and metestrous plus diestrous phases. Administration of gonadotropin leads to a similar increase in the capacity of the ovary to metabolize xenobiotics. This variation in the activity of 7,12-dimethylbenz[a]anthracene hydroxylase during the estrous cycle may be related to the marked changes in the incidence of ovarian cancer during menopause and in women taking contraceptive pills.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)