Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 March 1983:
Vol. 219. no. 4590, pp. 1345 - 1347
DOI: 10.1126/science.6828864
Prev | Table of Contents | Next

Articles

Science, Vol 219, Issue 4590, 1345-1347
Copyright © 1983 by American Association for the Advancement of Science

articles

Specific reading disability: identification of an inherited form through linkage analysis

SD Smith, WJ Kimberling, BF Pennington, and HA Lubs

Linkage analysis in families with apparent autosomal dominant reading disability produced a lod score of 3.241. Since the traditionally accepted significance level for linkage is a lod score of 3.0, these results strongly suggest that a gene playing a major etiologic role in one form of reading disability is on chromosome 15.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetics of dyslexia: the evolving landscape.
J. Schumacher, P. Hoffmann, C. Schmal, G. Schulte-Korne, and M. M Nothen (2007)
J. Med. Genet. 44, 289-297
   Abstract »    Full Text »    PDF »
The Genetic Bases of Speech Sound Disorders: Evidence From Spoken and Written Language.
B. A. Lewis, L. D. Shriberg, L. A. Freebairn, A. J. Hansen, C. M. Stein, H. G. Taylor, and S. K. Iyengar (2006)
J Speech Lang Hear Res 49, 1294-1312
   Abstract »    Full Text »    PDF »
From The Cover: DCDC2 is associated with reading disability and modulates neuronal development in the brain.
H. Meng, S. D. Smith, K. Hager, M. Held, J. Liu, R. K. Olson, B. F. Pennington, J. C. DeFries, J. Gelernter, T. O'Reilly-Pol, et al. (2005)
PNAS 102, 17053-17058
   Abstract »    Full Text »    PDF »
Male Vulnerability to Reading Disability Is Not Likely to Be a Myth: A Call for New Data.
J. Liederman, L. Kantrowitz, and K. Flannery (2005)
J Learn Disabil 38, 109-129
   Abstract »    PDF »
Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK.
T S Scerri, S E Fisher, C Francks, I L MacPhie, S Paracchini, A J Richardson, J F Stein, and A P Monaco (2004)
J. Med. Genet. 41, 853-857
   Full Text »    PDF »
A locus on 15q15-15qter influences dyslexia: further support from a transmission/disequilibrium study in an Italian speaking population.
C Marino, R Giorda, L Vanzin, M Nobile, M L Lorusso, C Baschirotto, L Riva, M Molteni, and M Battaglia (2004)
J. Med. Genet. 41, 42-46
   Full Text »    PDF »
The first candidate gene for dyslexia: Turning the page of a new chapter of research.
E. L. Grigorenko (2003)
PNAS 100, 11190-11192
   Full Text »    PDF »
From the Cover: A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain.
M. Taipale, N. Kaminen, J. Nopola-Hemmi, T. Haltia, B. Myllyluoma, H. Lyytinen, K. Muller, M. Kaaranen, P. J. Lindsberg, K. Hannula-Jouppi, et al. (2003)
PNAS 100, 11553-11558
   Abstract »    Full Text »    PDF »
Significance of Planum Temporale and Planum Parietale Morphologic Features in Neurofibromatosis Type 1.
R. L. Billingsley, G. W. Schrimsher, E. F. Jackson, J. M. Slopis, and B. D. Moore III (2002)
Arch Neurol 59, 616-622
   Abstract »    Full Text »    PDF »
Emerging Issues in the Genetics of Dyslexia: A Methodological Preview.
F. B. Wood and E. L. Grigorenko (2001)
J Learn Disabil 34, 503-511
   Abstract »    PDF »
A dominant gene for developmental dyslexia on chromosome 3.
J. Nopola-Hemmi, B. Myllyluoma, T. Haltia, M. Taipale, V. Ollikainen, T. Ahonen, A. Voutilainen, J. Kere, and E. Widen (2001)
J. Med. Genet. 38, 658-664
   Abstract »    Full Text »    PDF »
Two translocations of chromosome 15q associated with dyslexia.
J. Nopola-Hemmi, M. Taipale, T. Haltia, A.-E. Lehesjoki, A. Voutilainen, and J. Kere (2000)
J. Med. Genet. 37, 771-775
   Abstract »    Full Text »
Reliability and Validity of the Adult Reading History Questionnaire.
D. L. Lefly and B. F. Pennington (2000)
J Learn Disabil 33, 286-296
   Abstract »    PDF »
Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q.
D. W. Morris, L. Robinson, D. Turic, M. Duke, V. Webb, C. Milham, E. Hopkin, K. Pound, S. Fernando, M. Easton, et al. (2000)
Hum. Mol. Genet. 9, 843-848
   Abstract »    Full Text »    PDF »
Genetic Susceptibility to Neurodevelopmental Disorders.
S. G. Ryan (1999)
J Child Neurol 14, 187-195
   Abstract »    PDF »
Quantitative trait locus for reading disability on chromosome 6.
L. Cardon, S. Smith, D. Fulker, W. Kimberling, B. Pennington, and J. DeFries (1994)
Science 266, 276-279
   Abstract »    PDF »
The genetic basis of complex human behaviors.
R Plomin, M. Owen, and P McGuffin (1994)
Science 264, 1733-1739
   Abstract »    PDF »
Pedigree Analysis of Children with Phonology Disorders.
B. A. Lewis (1992)
J Learn Disabil 25, 586-597
   Abstract »    PDF »
Dyslexia at The New York Times: (Mis)Understanding of Parallel Visual Processing.
A. A. Sadun (1992)
Arch Ophthalmol 110, 933-934
   Abstract »    PDF »
Historical Perspectives on Dyslexia.
S. O. Richardson (1992)
J Learn Disabil 25, 40-47
   Abstract »    PDF »
Evidence for Major Gene Transmission of Developmental Dyslexia.
B. F. Pennington, J. W. Gilger, D. Pauls, S. A. Smith, S. D. Smith, and J. C. DeFries (1991)
JAMA 266, 1527-1534
   Abstract »    PDF »
The role of inheritance in behavior.
R Plomin (1990)
Science 248, 183-188
   Abstract »    PDF »
Gender Differences in Intelligence, Language, Visual-Motor Abilities, and Academic Achievement in Students with Learning Disabilities: A Review of the Literature.
S. A. Vogel (1990)
J Learn Disabil 23, 44-52
   Abstract »    PDF »
Specific Deficits in Component Reading and Language Skills: Genetic and Environmental Influences.
R. Olson, B. Wise, F. Conners, J. Rack, and D. Fulker (1989)
J Learn Disabil 22, 339-348
   Abstract »    PDF »
Dyslexia and Neurodevelopmental Pathology: Relationships to Cognition, Intelligence, and Reading Skill Acquisition.
G. W. Hynd and M. Semrud-Clikeman (1989)
J Learn Disabil 22, 204-216
   Abstract »    PDF »
Left-Handedness and Immune Disorders in Familial Dyslexics.
B. F. Pennington, S. D. Smith, W. J. Kimberling, P. A. Green, and M. M. Haith (1987)
Arch Neurol 44, 634-639
   Abstract »    PDF »
Do Learning Handicaps and Headache Cluster?.
A. Leviton (1986)
J Child Neurol 1, 372-377
   Abstract »    PDF »
Decoding, Reading, and Reading Disability.
P. B. Gough and W. E. Tunmer (1986)
Remedial and Special Education 7, 6-10
   Abstract »    PDF »
Cerebral Lateralization: Biological Mechanisms, Associations, and Pathology: II. A Hypothesis and a Program for Research.
N. Geschwind and A. M. Galaburda (1985)
Arch Neurol 42, 521-552
   Abstract »    PDF »
Gilles de la Tourette's Syndrome: A Review of Clinical and Research Studies and Consideration of Future Directions for Investigation.
E. D. Caine (1985)
Arch Neurol 42, 393-397
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)