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Science 18 March 1983:
Vol. 219. no. 4590, pp. 1337 - 1339
DOI: 10.1126/science.6402817
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Articles

Science, Vol 219, Issue 4590, 1337-1339
Copyright © 1983 by American Association for the Advancement of Science

articles

H-2 antigen class: effect on mouse islet allograft rejection

CE Morrow, DE Sutherland, MW Steffes, JS Najarian, and FH Bach

Rejection of mouse pancreatic islet allografts occurred in a high percentage of donor recipient combinations identical for H-21-region antigens and differing at H-2K and H-2K + H-2D without I-region disparities. The results suggest that disparities in major histocompatibility complex antigens of class I (H-2K and H-2D) alone are capable of eliciting islet allograft rejection, and that lack of a stimulus from class II (I-region) alloantigens does not ensure permanent islet allograft survival.




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