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Science 18 March 1983:
Vol. 219. no. 4590, pp. 1329 - 1331
DOI: 10.1126/science.6572416
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Articles

Science, Vol 219, Issue 4590, 1329-1331
Copyright © 1983 by American Association for the Advancement of Science

articles

Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo

MB Sporn, AB Roberts, JH Shull, JM Smith, JM Ward, and J Sodek

Transforming growth factors, which are polypeptides that induce the transformed phenotype in nonneoplastic cells, have been isolated in bulk amounts from bovine salivary gland and kidney. In experiments in which wound healing chambers were implanted subcutaneously in the backs of rats, these bovine transforming growth factors accelerated the accumulation of total protein, collagen, and DNA in treated chambers. These studies thus show an effect of an isolated transforming growth factor in vivo.


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