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Science 11 March 1983:
Vol. 219. no. 4589, pp. 1233 - 1235
DOI: 10.1126/science.6131537
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Articles

Science, Vol 219, Issue 4589, 1233-1235
Copyright © 1983 by American Association for the Advancement of Science

articles

Some neurons of the rat central nervous system contain aromatic-L-amino-acid decarboxylase but not monoamines

CB Jaeger, G Teitelman, TH Joh, VR Albert, DH Park, and DJ Reis

Neurons containing the enzyme aromatic-L-amino-acid decarboxylase (AADC) but lacking either tyrosine hydroxylase or serotonin were found in the spinal cord of neonatal and adult rats by light and electron microscopic immunocytochemistry. The majority of these neurons localized to area X of Rexed contact ependyma. Thus, spinal AADC neurons have the enzymatic capacity to catalyze directly the conversion of the amino acids tyrosine, tryptophan, or phenylalanine to their respective amines tyramine, tryptamine, or phenylethylamine. These amines normally present in the central nervous system may be of potential clinical significance as endogenous psychotomimetics.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evidence for the Existence of Homologous Gene Coding Regions for the Catecholamine Biosynthetic Enzymes.
T.H. Joh, E.E. Baetge, M.E. Ross, and D.J. Reis (1983)
Cold Spring Harb Symp Quant Biol 48, 327-335
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