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Science 25 February 1983:
Vol. 219. no. 4587, pp. 989 - 991
DOI: 10.1126/science.6130601
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Articles

Science, Vol 219, Issue 4587, 989-991
Copyright © 1983 by American Association for the Advancement of Science

articles

Suppression of epididymal sperm antigenicity in the rabbit by uteroglobin and transglutaminase in vitro

DC Mukherjee, AK Agrawal, R Manjunath, and AB Mukherjee

There is evidence that the mammalian female genital tract is capable of responding immunologically when challenged with alloantigens. The antigenic properties of male gametes have been well delineated. However, it is only rarely that a female mammal ever responds immunologically to the male gametic antigens as a result of coitus. When a proposed mechanism of suppression of antigenicity of epididymal spermatozoa was tested experimentally, the results indicated that two proteins (uteroglobin and transglutaminase) present in the prostate may be responsible for suppressing sperm antigenicity in the rabbit.


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Transglutaminase-mediated modifications of the rat sperm surface in vitro.
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