Science 25 February 1983: Vol. 219. no. 4587, pp. 979 - 980 DOI: 10.1126/science.6823561

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Articles

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair.

O. Rothfuss, H. Fischer, T. Hasegawa, M. Maisel, P. Leitner, F. Miesel, M. Sharma, A. Bornemann, D. Berg, T. Gasser, et al. (2009)
Hum. Mol. Genet. 18, 3832-3850
 |  Abstract »  |  Full Text »  |  PDF »

Four Decades of Neurodegenerative Disease Research: How Far We Have Come!.

A. B. Young (2009)
J. Neurosci. 29, 12722-12728
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Occupation and Risk of Parkinsonism: A Multicenter Case-Control Study.

C. M. Tanner, G. W. Ross, S. A. Jewell, R. A. Hauser, J. Jankovic, S. A. Factor, S. Bressman, A. Deligtisch, C. Marras, K. E. Lyons, et al. (2009)
Arch Neurol 66, 1106-1113
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Targeting neural precursors in the adult brain rescues injured dopamine neurons.

A. Androutsellis-Theotokis, M. A. Rueger, D. M. Park, H. Mkhikian, E. Korb, S. W. Poser, S. Walbridge, J. Munasinghe, A. P. Koretsky, R. R. Lonser, et al. (2009)
PNAS 106, 13570-13575
 |  Abstract »  |  Full Text »  |  PDF »

The scientific and clinical basis for the treatment of Parkinson disease (2009).

C. W. Olanow, M. B. Stern, and K. Sethi (2009)
Neurology 72, S1-S136
 |  Abstract »  |  Full Text »  |  PDF »

Deep Brain Stimulation: Avoiding the Errors of Psychosurgery.

M. L. Kringelbach and T. Z. Aziz (2009)
JAMA 301, 1705-1707
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Parkinson's Disease and Residential Exposure to Maneb and Paraquat From Agricultural Applications in the Central Valley of California.

S. Costello, M. Cockburn, J. Bronstein, X. Zhang, and B. Ritz (2009)
Am. J. Epidemiol. 169, 919-926
 |  Abstract »  |  Full Text »  |  PDF »

Glial Cells as Players in Parkinsonism: The "Good," the "Bad," and the "Mysterious" Glia.

M. A. Mena and J. Garcia de Yebenes (2008)
Neuroscientist 14, 544-560
 |  Abstract »  |  PDF »

Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease.

X. Hu, D. Zhang, H. Pang, W. M. Caudle, Y. Li, H. Gao, Y. Liu, L. Qian, B. Wilson, D. A. Di Monte, et al. (2008)
J. Immunol. 181, 7194-7204
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1{alpha}: regulation by SUMOylation and oxidation.

N. Zhong and J. Xu (2008)
Hum. Mol. Genet. 17, 3357-3367
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.

W.-S. Choi, S. E. Kruse, R. D. Palmiter, and Z. Xia (2008)
PNAS 105, 15136-15141
 |  Abstract »  |  Full Text »  |  PDF »

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.

H. Deng, M. W. Dodson, H. Huang, and M. Guo (2008)
PNAS 105, 14503-14508
 |  Abstract »  |  Full Text »  |  PDF »

Serine 129 Phosphorylation of {alpha}-Synuclein Induces Unfolded Protein Response-mediated Cell Death.

N. Sugeno, A. Takeda, T. Hasegawa, M. Kobayashi, A. Kikuchi, F. Mori, K. Wakabayashi, and Y. Itoyama (2008)
J. Biol. Chem. 283, 23179-23188
 |  Abstract »  |  Full Text »  |  PDF »

Progress in the pathogenesis and genetics of Parkinson's disease.

Y. Mizuno, N. Hattori, S.-i. Kubo, S. Sato, K. Nishioka, T. Hatano, H. Tomiyama, M. Funayama, Y. Machida, and H. Mochizuki (2008)
Phil Trans R Soc B 363, 2215-2227
 |  Abstract »  |  Full Text »  |  PDF »

Nmnat Delays Axonal Degeneration Caused by Mitochondrial and Oxidative Stress.

C. Press and J. Milbrandt (2008)
J. Neurosci. 28, 4861-4871
 |  Abstract »  |  Full Text »  |  PDF »

{alpha}-Synuclein, pesticides, and Parkinson disease: A case-control study.

L. Brighina, R. Frigerio, N. K. Schneider, T. G. Lesnick, M. de Andrade, J. M. Cunningham, M. J. Farrer, S. J. Lincoln, H. Checkoway, W. A. Rocca, et al. (2008)
Neurology 70, 1461-1469
 |  Abstract »  |  Full Text »  |  PDF »

Effect of (R)-Salsolinol and N-Methyl-(R)-Salsolinol on the Balance Impairment Between Dopamine and Acetylcholine in Rat Brain: Involvement in Pathogenesis of Parkinson Disease.

W. Zhu, D. Wang, J. Zheng, Y. An, Q. Wang, W. Zhang, L. Jin, H. Gao, and L. Lin (2008)
Clin. Chem. 54, 705-712
 |  Abstract »  |  Full Text »  |  PDF »

Paraquat Neurotoxicity Is Mediated by a Bak-dependent Mechanism.

Q. Fei, A. L. McCormack, D. A. Di Monte, and D. W. Ethell (2008)
J. Biol. Chem. 283, 3357-3364
 |  Abstract »  |  Full Text »  |  PDF »

Paraquat: The Red Herring of Parkinson's Disease Research.

G. W. Miller (2007)
Toxicol. Sci. 100, 1-2
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Parkinson's disease.

B. Thomas and M. F. Beal (2007)
Hum. Mol. Genet. 16, R183-R194
 |  Abstract »  |  Full Text »  |  PDF »

Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study.

F D Dick, G De Palma, A Ahmadi, N W Scott, G J Prescott, J Bennett, S Semple, S Dick, C Counsell, P Mozzoni, et al. (2007)
Occup. Environ. Med. 64, 666-672
 |  Abstract »  |  Full Text »  |  PDF »

Exacerbation of Dopaminergic Terminal Damage in a Mouse Model of Parkinson's Disease by the G-Protein-Coupled Receptor Protease-Activated Receptor 1.

C. E. Hamill, W. M. Caudle, J. R. Richardson, H. Yuan, K. D. Pennell, J. G. Greene, G. W. Miller, and S. F. Traynelis (2007)
Mol. Pharmacol. 72, 653-664
 |  Abstract »  |  Full Text »  |  PDF »

Annonacin, a Natural Mitochondrial Complex I Inhibitor, Causes Tau Pathology in Cultured Neurons.

M. Escobar-Khondiker, M. Hollerhage, M.-P. Muriel, P. Champy, A. Bach, C. Depienne, G. Respondek, E. S. Yamada, A. Lannuzel, T. Yagi, et al. (2007)
J. Neurosci. 27, 7827-7837
 |  Abstract »  |  Full Text »  |  PDF »

Physiology versus pathology in Parkinson's disease.

K. Nakamura and R. H. Edwards (2007)
PNAS 104, 11867-11868
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A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases.

W. Mandemakers, V. A. Morais, and B. De Strooper (2007)
J. Cell Sci. 120, 1707-1716
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Genetic and Environmental Factors in a Drosophila Parkinsonism Model.

A. Chaudhuri, K. Bowling, C. Funderburk, H. Lawal, A. Inamdar, Z. Wang, and J. M. O'Donnell (2007)
J. Neurosci. 27, 2457-2467
 |  Abstract »  |  Full Text »  |  PDF »

Parkinson's disease and pesticide exposures.

F. D. Dick (2007)
Br. Med. Bull.
 |  Abstract »  |  Full Text »  |  PDF »

Divergent Mechanisms of Paraquat, MPP+, and Rotenone Toxicity: Oxidation of Thioredoxin and Caspase-3 Activation.

S. Ramachandiran, J. M. Hansen, D. P. Jones, J. R. Richardson, and G. W. Miller (2007)
Toxicol. Sci. 95, 163-171
 |  Abstract »  |  Full Text »  |  PDF »

Obligatory Role for Complex I Inhibition in the Dopaminergic Neurotoxicity of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

J. R. Richardson, W. M. Caudle, T. S. Guillot, J. L. Watson, E. Nakamaru-Ogiso, B. B. Seo, T. B. Sherer, J. T. Greenamyre, T. Yagi, A. Matsuno-Yagi, et al. (2007)
Toxicol. Sci. 95, 196-204
 |  Abstract »  |  Full Text »  |  PDF »

A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation.

Y. S. Kim, D. H. Choi, M. L. Block, S. Lorenzl, L. Yang, Y. J. Kim, S. Sugama, B. P. Cho, O. Hwang, S. E. Browne, et al. (2007)
FASEB J 21, 179-187
 |  Abstract »  |  Full Text »  |  PDF »

Building the power house: recent advances in mitochondrial studies through proteomics and systems biology.

T. D. Vo and B. O. Palsson (2007)
Am J Physiol Cell Physiol 292, C164-C177
 |  Abstract »  |  Full Text »  |  PDF »

Present and future approaches to Parkinson disease: from molecular insights to new therapeutic avenues..

R. G. Fariello and A. Lieberman (2006)
Neurology 67, S1-S4
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A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease..

L. Zecca, F. A. Zucca, A. Albertini, E. Rizzio, and R. G. Fariello (2006)
Neurology 67, S8-11
 |  Abstract »  |  Full Text »

Low Concentrations of Paraquat Induces Early Activation of Extracellular Signal-Regulated Kinase 1/2, Protein Kinase B, and c-Jun N-terminal Kinase 1/2 Pathways: Role of c-Jun N-Terminal Kinase in Paraquat-Induced Cell Death.

M. Niso-Santano, J. M. Moran, L. Garcia-Rubio, A. Gomez-Martin, R. A. Gonzalez-Polo, G. Soler, and J. M. Fuentes (2006)
Toxicol. Sci. 92, 507-515
 |  Abstract »  |  Full Text »  |  PDF »

Proteomic Identification of a Stress Protein, Mortalin/mthsp70/GRP75: Relevance To Parkinson Disease.

J. Jin, C. Hulette, Y. Wang, T. Zhang, C. Pan, R. Wadhwa, and J. Zhang (2006)
Mol. Cell. Proteomics 5, 1193-1204
 |  Abstract »  |  Full Text »  |  PDF »

Surgical insights into Parkinson's disease..

E. A C Pereira and T. Z Aziz (2006)
J R Soc Med 99, 238-244
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondria in Parkinson disease: back in fashion with a little help from genetics..

M. M. K. Muqit, S. Gandhi, and N. W. Wood (2006)
Arch Neurol 63, 649-654
 |  Abstract »  |  Full Text »  |  PDF »

Parkinson's disease and primate research: past, present, and future..

E A C Pereira and T Z Aziz (2006)
Postgrad. Med. J. 82, 293-299
 |  Abstract »  |  Full Text »  |  PDF »

Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways..

S.-L. Hsuan, H. M. Klintworth, and Z. Xia (2006)
J. Neurosci. 26, 4481-4491
 |  Abstract »  |  Full Text »  |  PDF »

Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice..

R. Mejias, J. Villadiego, C. O. Pintado, P. J. Vime, L. Gao, J. J. Toledo-Aral, M. Echevarria, and J. Lopez-Barneo (2006)
J. Neurosci. 26, 4500-4508
 |  Abstract »  |  Full Text »  |  PDF »

Neuroanatomical Phenotyping in the Mouse: The Dopaminergic System.

C. J. Zeiss (2005)
Vet. Pathol. 42, 753-773
 |  Abstract »  |  Full Text »  |  PDF »

Paraquat Neurotoxicity is Distinct from that of MPTP and Rotenone.

J. R. Richardson, Y. Quan, T. B. Sherer, J. T. Greenamyre, and G. W. Miller (2005)
Toxicol. Sci. 88, 193-201
 |  Abstract »  |  Full Text »  |  PDF »

Torsin-Mediated Protection from Cellular Stress in the Dopaminergic Neurons of Caenorhabditis elegans.

S. Cao, C. C. Gelwix, K. A. Caldwell, and G. A. Caldwell (2005)
J. Neurosci. 25, 3801-3812
 |  Abstract »  |  Full Text »  |  PDF »

Parkinson's disease: the first common neurological disease due to auto-intoxication?.

A.C. Williams, L.S. Cartwright, and D.B. Ramsden (2005)
QJM 98, 215-226
 |  Abstract »  |  Full Text »  |  PDF »

Dopamine transporter SPECT in patients with mitochondrial disorders.

M Minnerop, C Kornblum, A Y Joe, K Tatsch, W S Kunz, T Klockgether, U Wullner, and M J Reinhardt (2005)
J. Neurol. Neurosurg. Psychiatry 76, 118-120
 |  Abstract »  |  Full Text »  |  PDF »

The neurotoxicology of hard foraging and fat-melts.

C. E. Finch (2004)
PNAS 101, 17887-17888
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Distinct Mechanisms of Neurodegeneration Induced by Chronic Complex I Inhibition in Dopaminergic and Non-dopaminergic Cells.

G.-R. Kweon, J. D. Marks, R. Krencik, E. H. Leung, P. T. Schumacker, K. Hyland, and U. J. Kang (2004)
J. Biol. Chem. 279, 51783-51792
 |  Abstract »  |  Full Text »  |  PDF »

A novel formulation of selegiline for the treatment of Parkinson's disease.

J. W. Tetrud and W. C. Koller (2004)
Neurology 63, S2-S6
 |  Full Text »

Dysregulation of Gene Expression in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Mouse Substantia Nigra.

R. M. Miller, L. M. Callahan, C. Casaceli, L. Chen, G. L. Kiser, B. Chui, T. M. Kaysser-Kranich, T. J. Sendera, C. Palaniappan, and H. J. Federoff (2004)
J. Neurosci. 24, 7445-7454
 |  Abstract »  |  Full Text »  |  PDF »

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.

H. Jiang, Y. Ren, J. Zhao, and J. Feng (2004)
Hum. Mol. Genet. 13, 1745-1754
 |  Abstract »  |  Full Text »  |  PDF »

Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor.

D. Marazziti, E. Golini, S. Mandillo, A. Magrelli, W. Witke, R. Matteoni, and G. P. Tocchini-Valentini (2004)
PNAS 101, 10189-10194
 |  Abstract »  |  Full Text »  |  PDF »

Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration: KEY SIGNALING PATHWAY FOR ASTROGLIOSIS IN VIVO?.

K. Sriram, S. A. Benkovic, M. A. Hebert, D. B. Miller, and J. P. O'Callaghan (2004)
J. Biol. Chem. 279, 19936-19947
 |  Abstract »  |  Full Text »  |  PDF »

Rotenone-Induced Apoptosis Is Mediated By p38 And JNK MAP Kinases In Human Dopaminergic SH-SY5Y Cells.

K. Newhouse, S.-L. Hsuan, S. H. Chang, B. Cai, Y. Wang, and Z. Xia (2004)
Toxicol. Sci. 79, 137-146
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice.

J. J. Palacino, D. Sagi, M. S. Goldberg, S. Krauss, C. Motz, M. Wacker, J. Klose, and J. Shen (2004)
J. Biol. Chem. 279, 18614-18622
 |  Abstract »  |  Full Text »  |  PDF »

1-Methyl-4-phenylpyridinium-induced Apoptosis in Cerebellar Granule Neurons Is Mediated by Transferrin Receptor Iron-dependent Depletion of Tetrahydrobiopterin and Neuronal Nitric-oxide Synthase-derived Superoxide.

T. Shang, S. Kotamraju, S. V. Kalivendi, C. J. Hillard, and B. Kalyanaraman (2004)
J. Biol. Chem. 279, 19099-19112
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome Mediates Dopaminergic Neuronal Degeneration, and Its Inhibition Causes {alpha}-Synuclein Inclusions.

H. Sawada, R. Kohno, T. Kihara, Y. Izumi, N. Sakka, M. Ibi, M. Nakanishi, T. Nakamizo, K. Yamakawa, H. Shibasaki, et al. (2004)
J. Biol. Chem. 279, 10710-10719
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Dopaminergic Loss by Fas in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease.

S. Hayley, S. J. Crocker, P. D. Smith, T. Shree, V. Jackson-Lewis, S. Przedborski, M. Mount, R. Slack, H. Anisman, and D. S. Park (2004)
J. Neurosci. 24, 2045-2053
 |  Abstract »  |  Full Text »  |  PDF »

Monoamine oxidase B inhibition and neuroprotection: Studies on selective adenosine A2A receptor antagonists.

N. Castagnoli Jr., J. P. Petzer, S. Steyn, K. Castagnoli, J.-F. Chen, M. A. Schwarzschild, and C. J. Van der Schyf (2003)
Neurology 61, S62-68
 |  Abstract »  |  Full Text »

The MPTP-treated primate as a model of motor complications in PD: Primate model of motor complications.

P. Jenner (2003)
Neurology 61, S4-11
 |  Abstract »  |  Full Text »

Neuroprotection in PD--A role for dopamine agonists?.

A.H. V. Schapira (2003)
Neurology 61, S34-42
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Sympathetic Innervation in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Primate Model of Parkinson's Disease.

D. S. Goldstein, S.-T. Li, C. Holmes, and K. Bankiewicz (2003)
J. Pharmacol. Exp. Ther. 306, 855-860
 |  Abstract »  |  Full Text »  |  PDF »

The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.

M. A. Wilson, J. L. Collins, Y. Hod, D. Ringe, and G. A. Petsko (2003)
PNAS 100, 9256-9261
 |  Abstract »  |  Full Text »  |  PDF »

Parkinson's disease: piecing together a genetic jigsaw.

M. C. J. Dekker, V. Bonifati, and C. M. van Duijn (2003)
Brain 126, 1722-1733
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for neurogenesis in the adult mammalian substantia nigra.

M. Zhao, S. Momma, K. Delfani, M. Carlen, R. M. Cassidy, C. B. Johansson, H. Brismar, O. Shupliakov, J. Frisen, and A. M. Janson (2003)
PNAS 100, 7925-7930
 |  Abstract »  |  Full Text »  |  PDF »

Impairment of context-adapted movement selection in a primate model of presymptomatic Parkinson's disease.

M. Pessiglione, D. Guehl, Y. Agid, E. C. Hirsch, J. Feger, and L. Tremblay (2003)
Brain 126, 1392-1408
 |  Abstract »  |  Full Text »  |  PDF »

Parkinsonian Mimetics Induce Aspects of Unfolded Protein Response in Death of Dopaminergic Neurons.

W. A. Holtz and K. L. O'Malley (2003)
J. Biol. Chem. 278, 19367-19377
 |  Abstract »  |  Full Text »  |  PDF »

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.

Y. Shu, M. K. Leabman, B. Feng, L. M. Mangravite, C. C. Huang, D. Stryke, M. Kawamoto, S. J. Johns, J. DeYoung, E. Carlson, et al. (2003)
PNAS 100, 5902-5907
 |  Abstract »  |  Full Text »  |  PDF »

Parkin Binds to alpha /beta Tubulin and Increases their Ubiquitination and Degradation.

Y. Ren, J. Zhao, and J. Feng (2003)
J. Neurosci. 23, 3316-3324
 |  Abstract »  |  Full Text »  |  PDF »

Update on Parkinson Disease.

A. Siderowf and M. Stern (2003)
Ann Intern Med 138, 651-658
 |  Abstract »  |  Full Text »  |  PDF »

Strong association between N-acetyltransferase 2 genotype and PD in Hong Kong Chinese.

D.K.Y. Chan, M.K.P. Lam, R. Wong, W.T. Hung, and D.E.L. Wilcken (2003)
Neurology 60, 1002-1005
 |  Abstract »  |  Full Text »  |  PDF »

Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cellular Models of Parkinson's Disease.

E. J. Ryu, H. P. Harding, J. M. Angelastro, O. V. Vitolo, D. Ron, and L. A. Greene (2002)
J. Neurosci. 22, 10690-10698
 |  Abstract »  |  Full Text »  |  PDF »

Irreversible Inhibition of CYP2D6 by (-)-Chloroephedrine, a Possible Impurity in Methamphetamine.

B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg, and W. H. Soine (2002)
Drug Metab. Dispos. 30, 1337-1343
 |  Abstract »  |  Full Text »  |  PDF »

Parkinson's disease and anaesthesia.

G. Nicholson, A. C. Pereira, and G. M. Hall (2002)
Br. J. Anaesth. 89, 904-916
 |  Abstract »  |  Full Text »  |  PDF »

2'-NH2-MPTP [1-Methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] Depletes Serotonin and Norepinephrine in Rats: A Comparison with 2'-CH3-MPTP [1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine].

E. L. Unger, P. Mazzola-Pomietto, D. L. Murphy, and A. M. Andrews (2002)
J. Pharmacol. Exp. Ther. 303, 527-533
 |  Abstract »  |  Full Text »  |  PDF »

Plantation Work and Risk of Parkinson Disease in a Population-Based Longitudinal Study.

H. Petrovitch, G. W. Ross, R. D. Abbott, W. T. Sanderson, D. S. Sharp, C. M. Tanner, K. H. Masaki, P. L. Blanchette, J. S. Popper, D. Foley, et al. (2002)
Arch Neurol 59, 1787-1792
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

W. Dauer, N. Kholodilov, M. Vila, A.-C. Trillat, R. Goodchild, K. E. Larsen, R. Staal, K. Tieu, Y. Schmitz, C. A. Yuan, et al. (2002)
PNAS 99, 14524-14529
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial Abnormalities and Oxidative Imbalance in Neurodegenerative Disease.

O. Ogawa, X. Zhu, G. Perry, and M. A. Smith (2002)
Sci. Aging Knowl. Environ. 2002, pe16-16
 |  Abstract »  |  Full Text »

Mitochondrial Therapy for Parkinson Disease.

R. N. Rosenberg (2002)
Arch Neurol 59, 1523
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Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline.

C. W. Shults, D. Oakes, K. Kieburtz, M. F. Beal, R. Haas, S. Plumb, J. L. Juncos, J. Nutt, I. Shoulson, J. Carter, et al. (2002)
Arch Neurol 59, 1541-1550
 |  Abstract »  |  Full Text »  |  PDF »

An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered alpha -Synuclein Metabolism and Oxidative Damage.

T. B. Sherer, R. Betarbet, A. K. Stout, S. Lund, M. Baptista, A. V. Panov, M. R. Cookson, and J. T. Greenamyre (2002)
J. Neurosci. 22, 7006-7015
 |  Abstract »  |  Full Text »  |  PDF »

Defining neurodegenerative diseases.

A. Williams (2002)
BMJ 324, 1465-1466
 |  Full Text »  |  PDF »

Environment, Mitochondria, and Parkinson's Disease.

T. B. Sherer, R. Betarbet, and J. T. Greenamyre (2002)
Neuroscientist 8, 192-197
 |  Abstract »  |  PDF »

The Globus Pallidus, Deep Brain Stimulation, and Parkinson's Disease.

J. O. Dostrovsky, W. D. Hutchison, and A. M. Lozano (2002)
Neuroscientist 8, 284-290
 |  Abstract »  |  PDF »

Caffeinated clues and the promise of adenosine A2A antagonists in PD.

M. A. Schwarzschild, J.-F. Chen, and A. Ascherio (2002)
Neurology 58, 1154-1160
 |  Abstract »  |  Full Text »  |  PDF »

Smoking and Parkinson's disease in twins.

C. M. Tanner, S. M. Goldman, D. A. Aston, R. Ottman, J. Ellenberg, R. Mayeux, and J. W. Langston (2002)
Neurology 58, 581-588
 |  Abstract »  |  Full Text »  |  PDF »

Treatment of early Parkinson's disease.

W. C. Koller (2002)
Neurology 58, S79-86
 |  Abstract »  |  Full Text »

Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour.

L Zecca, D Tampellini, M Gerlach, P Riederer, R G Fariello, and D Sulzer (2001)
Mol. Pathol. 54, 414-418
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Parkinsonism and occupational exposure to pesticides.

L S Engel, H Checkoway, M C Keifer, N S Seixas, W T Longstreth Jr, K C Scott, K Hudnell, W K Anger, and R Camicioli (2001)
Occup. Environ. Med. 58, 582-589
 |  Abstract »  |  Full Text »  |  PDF »

An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment.

C. W. Olanow, R. L. Watts, and W. C. Koller (2001)
Neurology 56, S1-S88
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Parkinson's disease, CYP2D6 polymorphism, and age.

H. Payami, N. Lee, S. Zareparsi, M. Gonzales McNeal, R. Camicioli, T.D. Bird, G. Sexton, S. Gancher, J. Kaye, D. Calhoun, et al. (2001)
Neurology 56, 1363-1370
 |  Abstract »  |  Full Text »  |  PDF »

Inducible expression of mutant {{alpha}}-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.

Y. Tanaka, S. Engelender, S. Igarashi, R. K. Rao, T. Wanner, R. E. Tanzi, A. Sawa, V. L. Dawson, T. M. Dawson, and C. A. Ross (2001)
Hum. Mol. Genet. 10, 919-926
 |  Abstract »  |  Full Text »  |  PDF »

The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese.

R.M. Wu, C.W. Cheng, K.H. Chen, S.L. Lu, D.E. Shan, Y.F. Ho, and H.D. Chern (2001)
Neurology 56, 375-382
 |  Abstract »  |  Full Text »  |  PDF »

Memory and executive function in sporadic and familial Parkinson's disease.

K. Dujardin, L. Defebvre, C. Grunberg, E. Becquet, and A. Destee (2001)
Brain 124, 389-398
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Temperature on Dopamine Transporter Function and Intracellular Accumulation of Methamphetamine: Implications for Methamphetamine-Induced Dopaminergic Neurotoxicity.

T. Xie, U. D. McCann, S. Kim, J. Yuan, and G. A. Ricaurte (2000)
J. Neurosci. 20, 7838-7845
 |  Abstract »  |  Full Text »  |  PDF »

Hydrocarbon exposure and Parkinson's disease.

G. Pezzoli, M. Canesi, A. Antonini, A. Righini, L. Perbellini, M. Barichella, C. B. Mariani, F. Tenconi, S. Tesei, A. Zecchinelli, et al. (2000)
Neurology 55, 667-673
 |  Abstract »  |  Full Text »  |  PDF »

Variability and validity of polymorphism association studies in Parkinson's disease.

E. K. Tan, M. Khajavi, J. I. Thornby, S. Nagamitsu, J. Jankovic, and T. Ashizawa (2000)
Neurology 55, 533-538
 |  Abstract »  |  Full Text »  |  PDF »

Dopamine-Deficient Mice Are Hypersensitive to Dopamine Receptor Agonists.

D. S. Kim, M. S. Szczypka, and R. D. Palmiter (2000)
J. Neurosci. 20, 4405-4413
 |  Abstract »  |  Full Text »  |  PDF »

Metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Perfused Rat Liver: Involvement of Hepatic Aldehyde Oxidase as a Detoxification Enzyme.

S.'i. Yoshihara, K. Harada, and S. Ohta (2000)
Drug Metab. Dispos. 28, 538-543
 |  Abstract »  |  Full Text »

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