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Science 18 February 1983: Vol. 219. no. 4586, pp. 856 - 859 DOI: 10.1126/science.6600519
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Articles
Science, Vol 219, Issue 4586, 856-859
Copyright © 1983 by American Association for the Advancement of Science
Isolation and transmission of human retrovirus (human t-cell leukemia virus)
M Popovic,
PS Sarin,
M Robert-Gurroff,
VS Kalyanaraman,
D Mann,
J Minowada,
and
RC Gallo
Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell leukemia patient. These people were from the United States, Israel, the West Indies, and Japan. The virus was detected in the fresh T cells and was isolated from the established T-cell lines. Each isolate is closely related to the first HTLV isolate, and all the new HTLV isolates were transmitted into normal human T cells obtained from the umbilical cord blood of newborns.
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