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Science 28 January 1983:
Vol. 219. no. 4583, pp. 414 - 416
DOI: 10.1126/science.6294835
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Articles

Science, Vol 219, Issue 4583, 414-416
Copyright © 1983 by American Association for the Advancement of Science

articles

A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam

WB Mendelson, M Cain, JM Cook, SM Paul, and P Skolnick

The benzodiazepine receptor antagonist 3-hydroxymethyl-beta-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-beta-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)