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Science 28 January 1983:
Vol. 219. no. 4583, pp. 405 - 408
DOI: 10.1126/science.6294834
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Articles

Science, Vol 219, Issue 4583, 405-408
Copyright © 1983 by American Association for the Advancement of Science

articles

Associative conditioning of single sensory neurons suggests a cellular mechanism for learning

ET Walters and JH Byrne

A cellular analog of associative learning has been demonstrated in individual sensory neurons of the tail withdrawal reflex of Aplysia. Sensory cells activated by intracellular current injection shortly before a sensitizing shock to the animal's tail display significantly more facilitation of their monosynaptic connections to a tail motor neuron than cells trained either with intracellular stimulation unpaired to tail shock or with tail shock alone. This associative effect is acquired rapidly and is expressed as a temporally specific amplification of heterosynaptic facilitation. The results suggest that activity-dependent neuromodulation may be a mechanism underlying associative information storage and point to aspects of subcellular processes that might be involved in the formation of neural associations.


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