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Science 21 January 1983:
Vol. 219. no. 4582, pp. 301 - 303
DOI: 10.1126/science.6129701
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Articles

Science, Vol 219, Issue 4582, 301-303
Copyright © 1983 by American Association for the Advancement of Science

articles

Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat

M Ligumsky, Y Goto, H Debas, and T Yamada

Somatostatin, a tetradecapeptide with potent inhibitory actions on gastric acid secretion, potentiated carbamylcholine-induced synthesis and release of prostaglandin E2 from isolated perfused rat stomachs. The ability of somatostatin to inhibit acid secretion was blocked by indomethacin, an inhibitor of prostaglandin synthesis. These results suggest that prostaglandins mediate gastric acid inhibition by somatostatin in the rat.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endogenous cyclo-oxygenase activity regulates mouse gastric surface pH.
H. K Baumgartner, U. Kirbiyik, T. Coskun, S. Chu, and M. H Montrose (2002)
J. Physiol. 544, 871-882
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