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Science 21 January 1983:
Vol. 219. no. 4582, pp. 245 - 250
DOI: 10.1126/science.219.4582.245
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Articles

Selectivity: A Key to Synthetic Efficiency

Barry M. Trost 1

1 Vilas and Helfaer Professor of Chemistry, McElvain Laboratories of Organic Chemistry, Department of Chemistry, University of Wisconsin, Madison 53706

The efficient synthesis of organic compounds requires the development of processes with enhanced selectivity. Selectivity is categorized according to chemical reactivity (chemoselectivity), orientation (regioselectivity), and spatial arrangement (diastereoselectivity and enantioselectivity). Recent developments in reduction-oxidation methods and C—C bond forming reactions illustrate some solutions to problems of selectivity. The design of selectivity-inducing groups and the increased role of main group and transition metals in enhancing selectivity are especially noted.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The atom economy--a search for synthetic efficiency.
B. Trost (1991)
Science 254, 1471-1477
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Current Status of Asymmetric Synthesis.
H. S. Mosher and J. D. Morrison (1983)
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Catalysts That Break Nature's Monopoly: Chiral complexes can approach the specificity of enzymes for synthesis of optically active compounds, and can act on a wider variety of substrates.
T. H. MAUGH II (1983)
Science 221, 351-354
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