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Science 7 January 1983:
Vol. 219. no. 4580, pp. 67 - 69
DOI: 10.1126/science.6849118
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Articles

Science, Vol 219, Issue 4580, 67-69
Copyright © 1983 by American Association for the Advancement of Science

articles

Parathyroid hormone: effects of the 3-34 fragment in vivo and vitro

JA McGowan, TC Chen, J Fragola, JB Puschett and M Rosenblatt

The biologically active fragment ofparathyroid hormone, consisting of residues 1-34, and its in vitro antagonist, fragment 3-34, were administered separately or in combination to chronically thyroparathyroidectomized dogs. These fragments were also studied in vitro with dog renal cortical membranes. Fragment 3-34 inhibited the stimulation of adenylate cyclase by fragment 1-34 in vitro, but had no agonist or antagonistic effects on renal phosphate transport in vivo.


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Arginine 186 in the Extracellular N-Terminal Region of the Human Parathyroid Hormone 1 Receptor Is Essential for Contact with Position 13 of the Hormone.
A. E. Adams, A. Bisello, M. Chorev, M. Rosenblatt, and L. J. Suva (1998)
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A parathyroid hormone inhibitor in vivo: design and biological evaluation of a hormone analog.
N Horiuchi, M. Holick, J. Potts Jr, and M Rosenblatt (1983)
Science 220, 1053-1055
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