Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 December 1982:
Vol. 218. no. 4579, pp. 1337 - 1339
DOI: 10.1126/science.6890713
Prev | Table of Contents

Articles

Science, Vol 218, Issue 4579, 1337-1339
Copyright © 1982 by American Association for the Advancement of Science

articles

The neuroanatomy of amnesia: amygdala-hippocampus versus temporal stem

S Zola-Morgan, LR Squire, and M Mishkin

Using a task known to be sensitive to human amnesia, we have evaluated two current hypotheses about which brain regions must be damaged to produce the disorder. Monkeys with bilateral transections of the white matter of the temporal stem were unimpaired, but monkeys with conjoint amygdala-hippocampal lesions exhibited a severe memory deficit. The results indicate that the hippocampus, amygdala, or both, but not the temporal stem, are involved in memory in the monkey and suggest that a rapprochement between the findings for the human and the nonhuman primate may be close at hand.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Positive Evidence against Human Hippocampal Involvement in Working Memory Maintenance of Familiar Stimuli.
E. Zarahn, B. Rakitin, D. Abela, J. Flynn, and Y. Stern (2005)
Cereb Cortex 15, 303-316
   Abstract »    Full Text »    PDF »
Enhanced Excitability Compensates for High-Pressure-Induced Depression of Cortical Inputs to the Hippocampus.
A. E. Talpalar and Y. Grossman (2004)
J Neurophysiol 92, 3309-3319
   Abstract »    Full Text »    PDF »
Long-Term Potentiation and Memory.
M. A. LYNCH (2004)
Physiol Rev 84, 87-136
   Abstract »    Full Text »    PDF »
Modulation of Rat Corticohippocampal Synaptic Activity by High Pressure and Extracellular Calcium: Single and Frequency Responses.
A. E. Talpalar and Y. Grossman (2003)
J Neurophysiol 90, 2106-2114
   Abstract »    Full Text »    PDF »
Effects of Combined and Separate Removals of Rostral Dorsal Superior Temporal Sulcus Cortex and Perirhinal Cortex on Visual Recognition Memory in Rhesus Monkeys.
W. S. Hadfield, M. G. Baxter, and E. A. Murray (2003)
J Neurophysiol 90, 2419-2427
   Abstract »    Full Text »    PDF »
Impaired Auditory Recognition Memory in Amnesic Patients with Medial Temporal Lobe Lesions.
L. R. Squire, H. Schmolck, and S. M. Stark (2001)
Learn. Mem. 8, 252-256
   Abstract »    Full Text »    PDF »
Impaired Recognition Memory in Rats after Damage to the Hippocampus.
R. E. Clark, S. M. Zola, and L. R. Squire (2000)
J. Neurosci. 20, 8853-8860
   Abstract »    Full Text »    PDF »
Glutamate infused posttraining into the hippocampus or caudate-putamen differentially strengthens place and response learning.
M. G. Packard (1999)
PNAS 96, 12881-12886
   Abstract »    Full Text »    PDF »
Effects of Ibotenate Hippocampal and Extrahippocampal Destruction on Delayed-Match and -Nonmatch-to-Sample Behavior in Rats.
R. E. Hampson, L. E. Jarrard, and S. A. Deadwyler (1999)
J. Neurosci. 19, 1492-1507
   Abstract »    Full Text »    PDF »
Object Recognition and Location Memory in Monkeys with Excitotoxic Lesions of the Amygdala and Hippocampus.
E. A. Murray and M. Mishkin (1998)
J. Neurosci. 18, 6568-6582
   Abstract »    Full Text »    PDF »
H. M.'s Medial Temporal Lobe Lesion: Findings from Magnetic Resonance Imaging.
S. Corkin, D. G. Amaral, R. G. Gonzalez, K. A. Johnson, and B. T. Hyman (1997)
J. Neurosci. 17, 3964-3979
   Abstract »    Full Text »    PDF »
The medial temporal lobe memory system.
L. Squire and S Zola-Morgan (1991)
Science 253, 1380-1386
   Abstract »    PDF »
Neuropsychological Correlates of Bilateral Amygdala Damage.
D. Tranel and B. T. Hyman (1990)
Arch Neurol 47, 349-355
   Abstract »    PDF »
The Prognosis of Transient Global Amnesia: Results of a Multicenter Study.
H.-H. Hinge, T. S. Jensen, M. Kjaer, J. Marquardsen, and B. de Fine Olivarius (1986)
Arch Neurol 43, 673-676
   Abstract »    PDF »
Mechanisms of memory.
L. Squire (1986)
Science 232, 1612-1619
   Abstract »    PDF »
Differential Patterns of Memory Loss Among Patients With Alzheimer's Disease, Huntington's Disease, and Alcoholic Korsakoff's Syndrome.
M. B. Moss, M. S. Albert, N. Butters, and M. Payne (1986)
Arch Neurol 43, 239-246
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)