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Science 24 December 1982:
Vol. 218. no. 4579, pp. 1311 - 1312
DOI: 10.1126/science.6183748
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Articles

Science, Vol 218, Issue 4579, 1311-1312
Copyright © 1982 by American Association for the Advancement of Science

articles

Virus-induced corticosterone in hypophysectomized mice: a possible lymphoid adrenal axis

EM Smith, WJ Meyer, and JE Blalock

Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced the differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.


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