Science 24 December 1982: Vol. 218. no. 4579, pp. 1309 - 1311 DOI: 10.1126/science.6815801

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Articles

Adoptive Transfer of T Lymphocytes Sensitized against the Prion Protein Attenuates Prion Invasion in Scrapie-Infected Mice.

P. Gourdain, S. Gregoire, S. Iken, V. Bachy, G. Dorban, T. Chaigneau, H. Debiec, A.-S. Bergot, I. Renault, P. Aucouturier, et al. (2009)
J. Immunol. 183, 6619-6628
 |  Abstract »  |  Full Text »  |  PDF »

The Effects of Host Age on Follicular Dendritic Cell Status Dramatically Impair Scrapie Agent Neuroinvasion in Aged Mice.

K. L. Brown, G. J. Wathne, J. Sales, M. E. Bruce, and N. A. Mabbott (2009)
J. Immunol. 183, 5199-5207
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Prions: Protein Aggregation and Infectious Diseases.

A. Aguzzi and A. M. Calella (2009)
Physiol Rev 89, 1105-1152
 |  Abstract »  |  Full Text »  |  PDF »

Measuring prions by bioluminescence imaging.

G. Tamguney, K. P. Francis, K. Giles, A. Lemus, S. J. DeArmond, and S. B. Prusiner (2009)
PNAS 106, 15002-15006
 |  Abstract »  |  Full Text »  |  PDF »

Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein.

C. Wolschner, A. Giese, H. A. Kretzschmar, R. Huber, L. Moroder, and N. Budisa (2009)
PNAS 106, 7756-7761
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Folding kinetics of the human prion protein probed by temperature jump.

T. Hart, L. L. P. Hosszu, C. R. Trevitt, G. S. Jackson, J. P. Waltho, J. Collinge, and A. R. Clarke (2009)
PNAS 106, 5651-5656
 |  Abstract »  |  Full Text »  |  PDF »

Prion Variants and Species Barriers Among Saccharomyces Ure2 Proteins.

H. K. Edskes, L. M. McCann, A. M. Hebert, and R. B. Wickner (2009)
Genetics 181, 1159-1167
 |  Abstract »  |  Full Text »  |  PDF »

Pathogenic prion protein is degraded by a manganese oxide mineral found in soils.

F. Russo, C. J. Johnson, C. J. Johnson, D. McKenzie, J. M. Aiken, and J. A. Pedersen (2009)
J. Gen. Virol. 90, 275-280
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Truncated Forms of Abnormal Prion Protein in Creutzfeldt-Jakob Disease.

S. Notari, R. Strammiello, S. Capellari, A. Giese, M. Cescatti, J. Grassi, B. Ghetti, J. P. M. Langeveld, W.-Q. Zou, P. Gambetti, et al. (2008)
J. Biol. Chem. 283, 30557-30565
 |  Abstract »  |  Full Text »  |  PDF »

Binding of Recombinant but Not Endogenous Prion Protein to DNA Causes DNA Internalization and Expression in Mammalian Cells.

S. Yin, X. Fan, S. Yu, C. Li, and M.-S. Sy (2008)
J. Biol. Chem. 283, 25446-25454
 |  Abstract »  |  Full Text »  |  PDF »

Protein Misfolding and Neurodegeneration.

C. Soto and L. D. Estrada (2008)
Arch Neurol 65, 184-189
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Depletion of CD11c+ Cells Impairs Scrapie Agent Neuroinvasion from the Intestine.

C. R. Raymond, P. Aucouturier, and N. A. Mabbott (2007)
J. Immunol. 179, 7758-7766
 |  Abstract »  |  Full Text »  |  PDF »

Ser170 controls the conformational multiplicity of the loop 166 175 in prion proteins: implication for conversion and species barrier.

A. A. Gorfe and A. Caflisch (2007)
FASEB J 21, 3279-3287
 |  Abstract »  |  Full Text »  |  PDF »

Efficient In Vitro Amplification of Chronic Wasting Disease PrPRES.

T. D. Kurt, M. R. Perrott, C. J. Wilusz, J. Wilusz, S. Supattapone, G. C. Telling, M. D. Zabel, and E. A. Hoover (2007)
J. Virol. 81, 9605-9608
 |  Abstract »  |  Full Text »  |  PDF »

Prions in the peripheral nerves of bovine spongiform encephalopathy-affected cattle.

K. Masujin, D. Matthews, G. A. H. Wells, S. Mohri, and T. Yokoyama (2007)
J. Gen. Virol. 88, 1850-1858
 |  Abstract »  |  Full Text »  |  PDF »

Role of the GALT in Scrapie Agent Neuroinvasion from the Intestine.

B. R. Glaysher and N. A. Mabbott (2007)
J. Immunol. 178, 3757-3766
 |  Abstract »  |  Full Text »  |  PDF »

Test for Detection of Disease-Associated Prion Aggregate in the Blood of Infected but Asymptomatic Animals.

B. Chang, X. Cheng, S. Yin, T. Pan, H. Zhang, P. Wong, S.-C. Kang, F. Xiao, H. Yan, C. Li, et al. (2007)
Clin. Vaccine Immunol. 14, 36-43
 |  Abstract »  |  Full Text »  |  PDF »

Insoluble Aggregates and Protease-resistant Conformers of Prion Protein in Uninfected Human Brains.

J. Yuan, X. Xiao, J. McGeehan, Z. Dong, I. Cali, H. Fujioka, Q. Kong, G. Kneale, P. Gambetti, and W.-Q. Zou (2006)
J. Biol. Chem. 281, 34848-34858
 |  Abstract »  |  Full Text »  |  PDF »

Prion Protein Expression by Mouse Dendritic Cells Is Restricted to the Nonplasmacytoid Subsets and Correlates with the Maturation State.

G. Martinez del Hoyo, M. Lopez-Bravo, P. Metharom, C. Ardavin, and P. Aucouturier (2006)
J. Immunol. 177, 6137-6142
 |  Abstract »  |  Full Text »  |  PDF »

PET-blot Analysis Contributes to BSE Strain Recognition in C57Bl/6 Mice.

S. Lezmi, A. Bencsik, and T. Baron (2006)
J. Histochem. Cytochem. 54, 1087-1094
 |  Abstract »  |  Full Text »  |  PDF »

A systematic review of prion therapeutics in experimental models.

C. R Trevitt and J. Collinge (2006)
Brain 129, 2241-2265
 |  Abstract »  |  Full Text »  |  PDF »

Amplified Immunohistochemical Detection of PrPsc in Animal Transmissible Spongiform Encephalopathies Using Streptomycin.

A. A. Bencsik, A. W. Coleman, S. O.S. Debeer, H. Perron, and A. Moussa (2006)
J. Histochem. Cytochem. 54, 849-853
 |  Abstract »  |  Full Text »  |  PDF »

Characterization and Application of a Novel RNA Aptamer against the Mouse Prion Protein..

S. Sekiya, K. Noda, F. Nishikawa, T. Yokoyama, P. K.R. Kumar, and S. Nishikawa (2006)
J. Biochem. 139, 383-390
 |  Abstract »  |  Full Text »  |  PDF »

Atypical prion protein in sheep brain collected during the British scrapie-surveillance programme.

S. J. Everest, L. Thorne, D. A. Barnicle, J. C. Edwards, H. Elliott, R. Jackman, and J. Hope (2006)
J. Gen. Virol. 87, 471-477
 |  Abstract »  |  Full Text »  |  PDF »

Potential Role of Soil in the Transmission of Prion Disease.

P. T. Schramm, C. J. Johnson, N. E. Mathews, D. McKenzie, J. M. Aiken, and J. A. Pedersen (2006)
Reviews in Mineralogy and Geochemistry 64, 135-152
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Computerized Morphometric Analysis of Pathological Prion Protein Deposition in Scrapie-Infected Hamster Brain.

O. A. Maximova, R. E. Taffs, K. L. Pomeroy, P. Piccardo, and D. M. Asher (2006)
J. Histochem. Cytochem. 54, 97-107
 |  Abstract »  |  Full Text »  |  PDF »

A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes.

A. Le Dur, V. Beringue, O. Andreoletti, F. Reine, T. L. Lai, T. Baron, B. Bratberg, J.-L. Vilotte, P. Sarradin, S. L. Benestad, et al. (2005)
PNAS 102, 16031-16036
 |  Abstract »  |  Full Text »  |  PDF »

An Aggregation-Specific Enzyme-Linked Immunosorbent Assay: Detection of Conformational Differences between Recombinant PrP Protein Dimers and PrPSc Aggregates.

T. Pan, B. Chang, P. Wong, C. Li, R. Li, S.-C. Kang, J. D. Robinson, A. R. Thompsett, P. Tein, S. Yin, et al. (2005)
J. Virol. 79, 12355-12364
 |  Abstract »  |  Full Text »  |  PDF »

An Alternative Pretreatment Procedure in Animal Transmissible Spongiform Encephalopathies Diagnosis Using PrPsc Immunohistochemistry.

A. A. Bencsik, S. O.S. Debeer, and T. G.M. Baron (2005)
J. Histochem. Cytochem. 53, 1199-1202
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of PrPC by Adenovirus-Mediated Gene Targeting Reduces Ischemic Injury in a Stroke Rat Model.

W.-C. Shyu, S.-Z. Lin, M.-F. Chiang, D.-C. Ding, K.-W. Li, S.-F. Chen, H.-I Yang, and H. Li (2005)
J. Neurosci. 25, 8967-8977
 |  Abstract »  |  Full Text »  |  PDF »

Protease-resistant Prion Protein Amplification Reconstituted with Partially Purified Substrates and Synthetic Polyanions.

N. R. Deleault, J. C. Geoghegan, K. Nishina, R. Kascsak, R. A. Williamson, and S. Supattapone (2005)
J. Biol. Chem. 280, 26873-26879
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Formation Modulates the Biological Activity of a Bacterial Protein.

S. Bieler, L. Estrada, R. Lagos, M. Baeza, J. Castilla, and C. Soto (2005)
J. Biol. Chem. 280, 26880-26885
 |  Abstract »  |  Full Text »  |  PDF »

High Incidence of Scrapie Induced by Repeated Injections of Subinfectious Prion Doses.

C. Jacquemot, C. Cuche, D. Dormont, and F. Lazarini (2005)
J. Virol. 79, 8904-8908
 |  Abstract »  |  Full Text »  |  PDF »

Molecular neurology of prion disease.

J Collinge (2005)
J. Neurol. Neurosurg. Psychiatry 76, 906-919
 |  Abstract »  |  Full Text »  |  PDF »

Expression of PrPC on cellular components of sheep blood.

S. Halliday, F. Houston, and N. Hunter (2005)
J. Gen. Virol. 86, 1571-1579
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Analysis of the Human and Chicken Prion Protein Copper Binding Regions at pH 6.5.

L. Redecke, W. Meyer-Klaucke, M. Koker, J. Clos, D. Georgieva, N. Genov, H. Echner, H. Kalbacher, M. Perbandt, R. Bredehorst, et al. (2005)
J. Biol. Chem. 280, 13987-13992
 |  Abstract »  |  Full Text »  |  PDF »

Novel Antibody-Lectin Enzyme-Linked Immunosorbent Assay That Distinguishes Prion Proteins in Sporadic and Variant Cases of Creutzfeldt-Jakob Disease.

T. Pan, R. Li, B.-S. Wong, S.-C. Kang, J. Ironside, and M.-S. Sy (2005)
J. Clin. Microbiol. 43, 1118-1126
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical Fingerprints of Prion Infection: Accumulations of Aberrant Full-Length and N-Terminally Truncated PrP Species Are Common Features in Mouse Prion Disease.

T. Pan, P. Wong, B. Chang, C. Li, R. Li, S.-C. Kang, T. Wisniewski, and M.-S. Sy (2005)
J. Virol. 79, 934-943
 |  Abstract »  |  Full Text »  |  PDF »

Glycosylation Deficiency at Either One of the Two Glycan Attachment Sites of Cellular Prion Protein Preserves Susceptibility to Bovine Spongiform Encephalopathy and Scrapie Infections.

E. Neuendorf, A. Weber, A. Saalmueller, H. Schatzl, K. Reifenberg, E. Pfaff, and M. H. Groschup (2004)
J. Biol. Chem. 279, 53306-53316
 |  Abstract »  |  Full Text »  |  PDF »

Ionic Strength and Transition Metals Control PrPSc Protease Resistance and Conversion-inducing Activity.

K. Nishina, S. Jenks, and S. Supattapone (2004)
J. Biol. Chem. 279, 40788-40794
 |  Abstract »  |  Full Text »  |  PDF »

Acute Formation of Protease-resistant Prion Protein Does Not Always Lead to Persistent Scrapie Infection in Vitro.

I. Vorberg, A. Raines, and S. A. Priola (2004)
J. Biol. Chem. 279, 29218-29225
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Different Experimental Conditions on the PrPSc Core Generated by Protease Digestion: IMPLICATIONS FOR STRAIN TYPING AND MOLECULAR CLASSIFICATION OF CJD.

S. Notari, S. Capellari, A. Giese, I. Westner, A. Baruzzi, B. Ghetti, P. Gambetti, H. A. Kretzschmar, and P. Parchi (2004)
J. Biol. Chem. 279, 16797-16804
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Molecular Analysis of the Abnormal Prion Protein in Field Scrapie Cases and Experimental Bovine Spongiform Encephalopathy in Sheep by Use of Western Blotting and Immunohistochemical Methods.

S. Lezmi, S. Martin, S. Simon, E. Comoy, A. Bencsik, J.-P. Deslys, J. Grassi, M. Jeffrey, and T. Baron (2004)
J. Virol. 78, 3654-3662
 |  Abstract »  |  Full Text »  |  PDF »

Prions: proteins as genes and infectious entities.

R. B. Wickner, H. K. Edskes, B. T. Roberts, U. Baxa, M. M. Pierce, E. D. Ross, and A. Brachmann (2004)
Genes & Dev. 18, 470-485
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Mutant PrPSc Conformers Induced by a Synthetic Peptide and Several Prion Strains.

P. Tremblay, H. L. Ball, K. Kaneko, D. Groth, R. S. Hegde, F. E. Cohen, S. J. DeArmond, S. B. Prusiner, and J. G. Safar (2004)
J. Virol. 78, 2088-2099
 |  Abstract »  |  Full Text »  |  PDF »

Games Played by Rogue Proteins in Prion Disorders and Alzheimer's Disease.

A. Aguzzi and C. Haass (2003)
Science 302, 814-818
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Novel Proteinase K-resistant C-terminal Fragments of PrP in Creutzfeldt-Jakob Disease.

W.-Q. Zou, S. Capellari, P. Parchi, M.-S. Sy, P. Gambetti, and S. G. Chen (2003)
J. Biol. Chem. 278, 40429-40436
 |  Abstract »  |  Full Text »  |  PDF »

Prions and the Oral Cavity.

A.J. Smith, J. Bagg, J.W. Ironside, R.G. Will, and C. Scully (2003)
Journal of Dental Research 82, 769-775
 |  Abstract »  |  Full Text »  |  PDF »

Influence of pH on NMR Structure and Stability of the Human Prion Protein Globular Domain.

L. Calzolai and R. Zahn (2003)
J. Biol. Chem. 278, 35592-35596
 |  Abstract »  |  Full Text »  |  PDF »

A novel generation of heparan sulfate mimetics for the treatment of prion diseases.

K. T. Adjou, S. Simoneau, N. Sales, F. Lamoury, D. Dormont, D. Papy-Garcia, D. Barritault, J.-P. Deslys, and C. I. Lasmezas (2003)
J. Gen. Virol. 84, 2595-2603
 |  Abstract »  |  Full Text »  |  PDF »

Variant Creutzfeldt-Jakob disease: pathology, epidemiology, and public health implications.

C. R Trevitt and P. N Singh (2003)
Am. J. Clinical Nutrition 78, 651S-656
 |  Abstract »  |  Full Text »  |  PDF »

Evaluation of Quinacrine Treatment for Prion Diseases.

A. Barret, F. Tagliavini, G. Forloni, C. Bate, M. Salmona, L. Colombo, A. De Luigi, L. Limido, S. Suardi, G. Rossi, et al. (2003)
J. Virol. 77, 8462-8469
 |  Abstract »  |  Full Text »  |  PDF »

Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility.

N. A. Mabbott, J. Young, I. McConnell, and M. E. Bruce (2003)
J. Virol. 77, 6845-6854
 |  Abstract »  |  Full Text »  |  PDF »

Introduction to the transmissible spongiform encephalopathies or prion diseases.

B. Chesebro (2003)
Br. Med. Bull. 66, 1-20
 |  Abstract »  |  Full Text »  |  PDF »

Sporadic and familial CJD: classification and characterisation.

P. Gambetti, Q. Kong, W. Zou, P. Parchi, and S. G Chen (2003)
Br. Med. Bull. 66, 213-239
 |  Abstract »  |  Full Text »  |  PDF »

Diagnosis of prion diseases.

E. Kubler, B. Oesch, and A. J Raeber (2003)
Br. Med. Bull. 66, 267-279
 |  Abstract »  |  Full Text »  |  PDF »

CD21-Positive Follicular Dendritic Cells: A Possible Source of PrPSc in Lymph Node Macrophages of Scrapie-Infected Sheep.

L. M. Herrmann, W. P. Cheevers, W. C. Davis, D. P. Knowles, and K. I. O'Rourke (2003)
Am. J. Pathol. 162, 1075-1081
 |  Abstract »  |  Full Text »  |  PDF »

Accumulation of Pathogenic Prion Protein (PrPSc) in Nervous and Lymphoid Tissues of Sheep with Subclinical Scrapie.

C. Ersdal, M. J. Ulvund, S. L. Benestad, and M. A. Tranulis (2003)
Vet. Pathol. 40, 164-174
 |  Abstract »  |  Full Text »  |  PDF »

Detection of PrPsc in Samples Presenting a Very Advanced Degree of Autolysis (BSE Liquid State) by Immunocytochemistry.

E. Monleon, M. Monzon, P. Hortells, A. Vargas, and J. J. Badiola (2003)
J. Histochem. Cytochem. 51, 15-18
 |  Abstract »  |  Full Text »  |  PDF »

Drug therapy in human and experimental transmissible spongiform encephalopathy.

P. Brown (2002)
Neurology 58, 1720-1725
 |  Abstract »  |  Full Text »  |  PDF »

Temporary Blockade of the Tumor Necrosis Factor Receptor Signaling Pathway Impedes the Spread of Scrapie to the Brain.

N. A. Mabbott, G. McGovern, M. Jeffrey, and M. E. Bruce (2002)
J. Virol. 76, 5131-5139
 |  Abstract »  |  Full Text »  |  PDF »

Transmissible Spongiform Encephalopathy Diagnosis Using PrPsc Immunohistochemistry on Fixed but Previously Frozen Brain Samples.

S. O.S. Debeer, T. G.M. Baron, and A. A. Bencsik (2002)
J. Histochem. Cytochem. 50, 611-616
 |  Abstract »  |  Full Text »  |  PDF »

Inaugural Article: Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein.

U. Baxa, V. Speransky, A. C. Steven, and R. B. Wickner (2002)
PNAS 99, 5253-5260
 |  Abstract »  |  Full Text »  |  PDF »

PrPSc Is Not Detected in Peripheral Blood Leukocytes of Scrapie-Infected Sheep: Determining the Limit of Sensitivity by Immunohistochemistry.

L. M. Herrmann, T. V. Baszler, D. P. Knowles, and W. P. Cheevers (2002)
Clin. Vaccine Immunol. 9, 499-502
 |  Abstract »  |  Full Text »  |  PDF »

Distribution and accumulation of PrP in gut-associated and peripheral lymphoid tissue of scrapie-affected Suffolk sheep.

R. Heggebo, C. McL. Press, G. Gunnes, L. Gonzalez, and M. Jeffrey (2002)
J. Gen. Virol. 83, 479-489
 |  Abstract »  |  Full Text »  |  PDF »

Migrating intestinal dendritic cells transport PrPSc from the gut.

F.-P. Huang, C. F. Farquhar, N. A. Mabbott, M. E. Bruce, and G. G. MacPherson (2002)
J. Gen. Virol. 83, 267-271
 |  Abstract »  |  Full Text »  |  PDF »

A Critical Review of the Nature of the Spongiform Encephalopathy Agent: Protein Theory Versus Virus Theory.

H. Narang (2002)
Experimental Biology and Medicine 227, 4-19
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of Histological Lesions and Immunohistochemical Staining of Proteinase-resistant Prion Protein in a Naturally Occurring Spongiform Encephalopathy of Free-ranging Mule Deer (Odocoileus hemionus) with Those of Chronic Wasting Disease of Captive Mule Deer.

T. R. Spraker, R. R. Zink, B. A. Cummings, M. A. Wild, M. W. Miller, and K. I. O'Rourke (2002)
Vet. Pathol. 39, 110-119
 |  Abstract »  |  Full Text »  |  PDF »

Immunohistochemistry of PrPsc Within Bovine Spongiform Encephalopathy Brain Samples with Graded Autolysis.

S. O.S. Debeer, T. G.M. Baron, and A. A. Bencsik (2001)
J. Histochem. Cytochem. 49, 1519-1524
 |  Abstract »  |  Full Text »  |  PDF »

The molecular pathology of CJD: old and new variants.

G S Jackson and J Collinge (2001)
Mol. Pathol. 54, 393-399
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of {beta}-Strand and {alpha}-Helix Secondary Structure in Normal Prion Protein Inhibits Formation of Its Protease-Resistant Isoform.

I. Vorberg, K. Chan, and S. A. Priola (2001)
J. Virol. 75, 10024-10032
 |  Abstract »  |  Full Text »  |  PDF »

Early Spread of Scrapie from the Gastrointestinal Tract to the Central Nervous System Involves Autonomic Fibers of the Splanchnic and Vagus Nerves.

P. A. McBride, W. J. Schulz-Schaeffer, M. Donaldson, M. Bruce, H. Diringer, H. A. Kretzschmar, and M. Beekes (2001)
J. Virol. 75, 9320-9327
 |  Abstract »  |  Full Text »  |  PDF »

The immunobiology of TSE diseases.

N. A. Mabbott and M. E. Bruce (2001)
J. Gen. Virol. 82, 2307-2318
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Prion Filament Networks in [Ure3] Cells of Saccharomyces cerevisiae.

V. V. Speransky, K. L. Taylor, H. K. Edskes, R. B. Wickner, and A. C. Steven (2001)
J. Cell Biol. 153, 1327-1336
 |  Abstract »  |  Full Text »  |  PDF »

Prion Proteins with Different Conformations Accumulate in Gerstmann-Straussler-Scheinker Disease Caused by A117V and F198S Mutations.

P. Piccardo, J. J. Liepnieks, A. William, S. R. Dlouhy, M. R. Farlow, K. Young, D. Nochlin, T. D. Bird, R. R. Nixon, M. J. Ball, et al. (2001)
Am. J. Pathol. 158, 2201-2207
 |  Abstract »  |  Full Text »  |  PDF »

Partial dissociation of PrPSc deposition and vacuolation in the brains of scrapie and BSE experimentally affected goats.

J. Foster, W. Goldmann, D. Parnham, A. Chong, and N. Hunter (2001)
J. Gen. Virol. 82, 267-273
 |  Abstract »  |  Full Text »

Distribution of prion protein in the ileal Peyer's patch of scrapie-free lambs and lambs naturally and experimentally exposed to the scrapie agent.

R. Heggebø, C. McL. Press, G. Gunnes, K. Inge Lie, M. A. Tranulis, M. Ulvund, M. H. Groschup, and T. Landsverk (2000)
J. Gen. Virol. 81, 2327-2337
 |  Abstract »  |  Full Text »

Opposite Effects of Dextran Sulfate 500, the Polyene Antibiotic MS-8209, and Congo Red on Accumulation of the Protease-Resistant Isoform of PrP in the Spleens of Mice Inoculated Intraperitoneally with the Scrapie Agent.

V. Beringue, K. T. Adjou, F. Lamoury, T. Maignien, J.-P. Deslys, R. Race, and D. Dormont (2000)
J. Virol. 74, 5432-5440
 |  Abstract »  |  Full Text »  |  PDF »

Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets.

J. Bieschke, A. Giese, W. Schulz-Schaeffer, I. Zerr, S. Poser, M. Eigen, and H. Kretzschmar (2000)
PNAS 97, 5468-5473
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor Alpha-Deficient, but Not Interleukin-6-Deficient, Mice Resist Peripheral Infection with Scrapie.

N. A. Mabbott, A. Williams, C. F. Farquhar, M. Pasparakis, G. Kollias, and M. E. Bruce (2000)
J. Virol. 74, 3338-3344
 |  Abstract »  |  Full Text »  |  PDF »

Prions in Saccharomyces and Podospora spp.: Protein-Based Inheritance.

R. B. Wickner, K. L. Taylor, H. K. Edskes, M.-L. Maddelein, H. Moriyama, and B. T. Roberts (1999)
Microbiol. Mol. Biol. Rev. 63, 844-861
 |  Abstract »  |  Full Text »  |  PDF »

Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents.

T. Maignien, C. I. Lasmé zas, V. Beringue, D. Dormont, and J.-P. Deslys (1999)
J. Gen. Virol. 80, 3035-3042
 |  Abstract »  |  Full Text »

PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease.

K. I. O'Rourke, T. E. Besser, M. W. Miller, T. F. Cline, T. R. Spraker, A. L. Jenny, M. A. Wild, G. L. Zebarth, and E. S. Williams (1999)
J. Gen. Virol. 80, 2765-2679
 |  Abstract »  |  Full Text »

Two Prion-Inducing Regions of Ure2p Are Nonoverlapping.

M.-L. Maddelein and R. B. Wickner (1999)
Mol. Cell. Biol. 19, 4516-4524
 |  Abstract »  |  Full Text »  |  PDF »

Effectiveness of Polyene Antibiotics in Treatment of Transmissible Spongiform Encephalopathy in Transgenic Mice Expressing Syrian Hamster PrP Only in Neurons.

R. Demaimay, R. Race, and B. Chesebro (1999)
J. Virol. 73, 3511-3513
 |  Abstract »  |  Full Text »  |  PDF »

The [URE3] prion is an aggregated form of Ure2p that can be cured by overexpression of Ure2p fragments.

H. K. Edskes, V. T. Gray, and R. B. Wickner (1999)
PNAS 96, 1498-1503
 |  Abstract »  |  Full Text »  |  PDF »

1755 and all that: a historical primer of transmissible spongiform encephalopathy.

P. Brown and R. Bradley (1998)
BMJ 317, 1688-1692
 |  Full Text »

Prions.

S. B. Prusiner (1998)
PNAS 95, 13363-13383
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous Proteolytic Cleavage of Normal and Disease-Associated Isoforms of the Human Prion Protein in Neural and Non-Neural Tissues.

A. Jimenez-Huete, P. M. J. Lievens, R. Vidal, P. Piccardo, B. Ghetti, F. Tagliavini, B. Frangione, and F. Prelli (1998)
Am. J. Pathol. 153, 1561-1572
 |  Abstract »  |  Full Text »  |  PDF »

Reversibility of Scrapie Inactivation Is Enhanced by Copper.

D. McKenzie, J. Bartz, J. Mirwald, D. Olander, R. Marsh, and J. Aiken (1998)
J. Biol. Chem. 273, 25545-25547
 |  Abstract »  |  Full Text »  |  PDF »

Monoclonal Antibody F89/160.1.5 Defines a Conserved Epitope on the Ruminant Prion Protein.

K. I. O'Rourke, T. V. Baszler, J. M. Miller, T. R. Spraker, I. Sadler-Riggleman, and D. P. Knowles (1998)
J. Clin. Microbiol. 36, 1750-1755
 |  Abstract »  |  Full Text »  |  PDF »

Prion Protein Expression in Human Leukocyte Differentiation.

V. C. Dodelet and N. R. Cashman (1998)
Blood 91, 1556-1561
 |  Abstract »  |  Full Text »  |  PDF »

Transmissible Spongiform Encephalopathies.

A. M. Haywood (1997)
N. Engl. J. Med. 337, 1821-1828
 |  Full Text »  |  PDF »

Commentary Review: Prion Diseases.

A. K. Shetty and R. W. Steele (1997)
Clinical Pediatrics 36, 1-7
 |  PDF »

Molecular Biology and Genetics of Prion Diseases.

S.B. Prusiner (1996)
Cold Spring Harb Symp Quant Biol 61, 473-493
 |  Abstract »  |  PDF »

Prions of Yeast, [PSI] and [URE3], as Models for Neurodegenerative Diseases.

R.B. Wickner, D.C. Masison, H.K. Edskes, and M.-L. Maddelein (1996)
Cold Spring Harb Symp Quant Biol 61, 541-550
 |  Abstract »  |  PDF »

Prion-Inducing Domain of Yeast Ure2p and Protease Resistance of Ure2p in Prion-Containing Cells.

D. C. Masison and R. B. Wickner (1995)
Science 270, 93-95
 |  Abstract »  |  PDF »

Prion Protein Isoforms, a Convergence of Biological and Structural Investigations.

M. A. Baldwin, F. E. Cohen, and S. B. Prusiner (1995)
J. Biol. Chem. 270, 19197-19200
 |  Full Text »  |  PDF »

A 60-kDa Prion Protein (PrP) with Properties of Both the Normal and Scrapie-associated Forms of PrP.

S. A. Priola, B. Caughey, K. Wehrly, and B. Chesebro (1995)
J. Biol. Chem. 270, 3299-3305
 |  Abstract »  |  Full Text »  |  PDF »

Genetic and Infectious Prion Diseases.

S. B. Prusiner (1993)
Arch Neurol 50, 1129-1153
 |  Abstract »  |  PDF »

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