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Science 10 December 1982:
Vol. 218. no. 4577, pp. 1134 - 1136
DOI: 10.1126/science.6128790
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Articles

Science, Vol 218, Issue 4577, 1134-1136
Copyright © 1982 by American Association for the Advancement of Science

articles

Comparison of the distribution of dynorphin systems and enkephalin systems in brain

SJ Watson, H Khachaturian, H Akil, DH Coy, and A Goldstein

A study of the anatomical distribution of the endogenous opioid dynorphin in rat brain showed that the peptide is localized in a widespread system with multiple cell groups and projections. This network is revealed by the use of multiple antiserums against dynorphin and can be distinguished from the system containing methionine-enkephalin and leucine-enkephalin, which is mapped by the use of antiserums against the enkephalins and biosynthetically related peptides in the adrenal. It thus appears that the brain contains at least three separate opioid neuronal networks: an enkephalin family with components similar to those found in the adrenal, a beta-endorphin family, and a dynorphin family.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dynorphin B Is an Agonist of Nuclear Opioid Receptors Coupling Nuclear Protein Kinase C Activation to the Transcription of Cardiogenic Genes in GTR1 Embryonic Stem Cells.
C. Ventura, E. Zinellu, E. Maninchedda, and M. Maioli (2003)
Circ. Res. 92, 623-629
   Abstract »    Full Text »    PDF »
Dopamine Release in the Nucleus Accumbens during Heroin Self-Administration Is Modulated by Kappa Opioid Receptors: An In Vivo Fast-Cyclic Voltammetry Study.
Z.-X. Xi, S. A. Fuller, and E. A. Stein (1998)
J. Pharmacol. Exp. Ther. 284, 151-161
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Topical Review: Basal Ganglia: Functional Anatomy and Physiology. Part 1.
A. K. Afifi (1994)
J Child Neurol 9, 249-260
   Abstract »    PDF »
Multiple Morphine and Enkephalin Receptors and the Relief of Pain.
G. W. Pasternak (1988)
JAMA 259, 1362-1367
   Abstract »    PDF »
Naloxone and Alzheimer's Disease: Cognitive and Behavioral Effects of a Range of Doses.
P. N. Tariot, T. Sunderland, H. Weingartner, D. L. Murphy, M. R. Cohen, and R. M. Cohen (1986)
Arch Gen Psychiatry 43, 727-732
   Abstract »    PDF »
Methionine and leucine enkephalin in rat neurohypophysis: different responses to osmotic stimuli and T2 toxin.
N Zamir, D Zamir, L. Eiden, M Palkovits, M. Brownstein, R. Eskay, E Weber, A. Faden, and G Feuerstein (1985)
Science 228, 606-608
   Abstract »    PDF »
Dynorphin-A-(1-8) is contained within vasopressin neurosecretory vesicles in rat pituitary.
M. Whitnall, H Gainer, B. Cox, and C. Molineaux (1983)
Science 222, 1137-1139
   Abstract »    PDF »
The Enkephalinergic Neuron: Implications of a Polyenkephalin Precursor.
J. Rossier, D. Liston, G. Patey, M. Chaminade, A.S. Foutz, A. Cupo, P. Giraud, M.P. Roisin, J.P. Henry, P. Verbanck, et al. (1983)
Cold Spring Harb Symp Quant Biol 48, 393-404
   Abstract »    PDF »


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