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Science 10 December 1982:
Vol. 218. no. 4577, pp. 1075 - 1082
DOI: 10.1126/science.6890712
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Articles

Science, Vol 218, Issue 4577, 1075-1082
Copyright © 1982 by American Association for the Advancement of Science

articles

New chemistry of an old molecule: cis-[Pt(NH3)2Cl2]

SJ Lippard

The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.


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Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium.
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Cisplatin.
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