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Science 26 November 1982:
Vol. 218. no. 4575, pp. 913 - 916
DOI: 10.1126/science.6182616
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Articles

Science, Vol 218, Issue 4575, 913-916
Copyright © 1982 by American Association for the Advancement of Science

articles

Rapid and precise down regulation of fast axonal transport of transmitter in an identified neuron

JM Aletta and DJ Goldberg

Within 1 day after the removal of one branch of the bifurcated axon of an identified neuron in Aplysia, the cell body reduced its output of transmitter storage vesicles to adjust precisely for the decreased need. This adjustment terminated the initial consequence of the removal, the transport of an inappropriately large number of vesicles to the remaining synapses. The most likely cause of the reduction of transport of transmitter is the loss of information normally provided by the disconnected axon or synapses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Functional Implications of Neurotransmitter Expression during Axonal Regeneration: Serotonin, But Not Peptides, Auto-Regulate Axon Growth of an Identified Central Neuron.
C. E. Koert, G. E. Spencer, J. van Minnen, K. W. Li, W. P. M. Geraerts, N. I. Syed, A. B. Smit, and R. E. van Kesteren (2001)
J. Neurosci. 21, 5597-5606
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