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Science 26 November 1982:
Vol. 218. no. 4575, pp. 894 - 896
DOI: 10.1126/science.7134979
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Articles

Science, Vol 218, Issue 4575, 894-896
Copyright © 1982 by American Association for the Advancement of Science

articles

Stimulation of feeding in rats by intraperitoneal injection of antibodies to glucagon

W Langhans, U Zeiger, E Scharrer, and N Geary

Intraperitoneal injections of antibodies to pancreatic glucagon at the onset of the first meal after 12 hours of food deprivation increased meal size 63 percent and meal duration 74 percent in rats. The antibodies also reduced the increase in hepatic vein blood glucose that occurred during meals in control rats, but did not affect the prandial increase in portal vein blood glucose. These results suggest that, under these conditions, pancreatic glucagon is necessary for the normal termination of meals.


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