Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 November 1982:
Vol. 218. no. 4573, pp. 686 - 688
DOI: 10.1126/science.6291150
Prev | Table of Contents | Next

Articles

Science, Vol 218, Issue 4573, 686-688
Copyright © 1982 by American Association for the Advancement of Science

articles

Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene

R Dalla-Favera, RC Gallo, A Giallongo, and CM Croce

Nonrandom chromosome rearrangements of chromosome 22 have been identified in different human malignancies. As a result of Southern blot hybridization of a c-sis probe to DNA's from mouse-human somatic cell hybrids, the human homolog (c-sis) of the transforming gene of simian sarcoma virus was assigned to chromosome 22. Hybrids between thymidine kinase-deficient mouse cells and human fibroblasts carrying a translocation of the region q11-qter of chromosome 22 to chromosome 17 were also analyzed. These studies demonstrate that the human c-sis gene is on region 22q11 greater than qter.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biology of Platelet-Derived Growth Factor and Its Involvement in Disease.
R. H. Alvarez, H. M. Kantarjian, and J. E. Cortes (2006)
Mayo Clin. Proc. 81, 1241-1257
   Abstract »    Full Text »    PDF »
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor.
C.-H. Heldin and B. Westermark (1999)
Physiol Rev 79, 1283-1316
   Abstract »    Full Text »    PDF »
Effect of Phenotype on the Transcription of the Genes for Platelet-Derived Growth Factor (PDGF) Isoforms in Human Smooth Muscle Cells, Monocyte-Derived Macrophages, and Endothelial Cells In Vitro.
A. Krettek, G. Fager, H. Lindmark, C. Simonson, and F. Lustig (1997)
Arterioscler Thromb Vasc Biol 17, 2897-2903
   Abstract »    Full Text »
Absence of Expression of c-sis and Transforming Growth Factor-{beta} mRNA in Malignant Fibrous Histiocytoma.
T. S. Frank, J. C. Reed, and J. S. J. Brooks (1993)
International Journal of Surgical Pathology 1, 117-121
   Abstract »    PDF »
Chronic Leukemias: Oncogenes, Chromosomes, and Advances in Therapy.
R. CHAMPLIN, R. P. GALE, K. A. FOON, and D. W. GOLDE (1986)
Ann Intern Med 104, 671-688
   Abstract »    PDF »
Chromosomal Mapping of Genes Involved in Growth Control.
U. Francke, T.L. Yang-Feng, J.E. Brissenden, and A. Ullrich (1986)
Cold Spring Harb Symp Quant Biol 51, 855-866
   Abstract »    PDF »
Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.
S. Josephs, L Ratner, M. Clarke, E. Westin, M. Reitz, and F Wong-Staal (1984)
Science 225, 636-639
   Abstract »    PDF »
Human-proto-oncogene nucleotide sequences corresponding to the transforming region of simian sarcoma virus.
S. Josephs, C Guo, L Ratner, and F Wong-Staal (1984)
Science 223, 487-491
   Abstract »    PDF »
Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1.
L. Seigel, M. Harper, F Wong-Staal, R. Gallo, W. Nash, and S. O'Brien (1984)
Science 223, 175-178
   Abstract »    PDF »
The human gene for the beta subunit of nerve growth factor is located on the proximal short arm of chromosome 1.
U Francke, B de Martinville, L Coussens, and A Ullrich (1983)
Science 222, 1248-1251
   Abstract »    PDF »
Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15.
C. Kozak, J. Sears, and M. Hoggan (1983)
Science 221, 867-869
   Abstract »    PDF »
The chromosomal basis of human neoplasia.
J. Yunis (1983)
Science 221, 227-236
   Abstract »    PDF »
Somatic cell genetics and gene families.
P D'Eustachio and F. Ruddle (1983)
Science 220, 919-924
   Abstract »    PDF »
Human c-Ki-ras2 proto-oncogene on chromosome 12.
A. Sakaguchi, S. Naylor, T. Shows, J. Toole, M McCoy, and R. Weinberg (1983)
Science 219, 1081-1083
   Abstract »    PDF »
Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas.
R Dalla-Favera, S Martinotti, R. Gallo, J Erikson, and C. Croce (1983)
Science 219, 963-967
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)