Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 November 1982:
Vol. 218. no. 4573, pp. 684 - 686
DOI: 10.1126/science.7134966
Prev | Table of Contents | Next

Articles

Science, Vol 218, Issue 4573, 684-686
Copyright © 1982 by American Association for the Advancement of Science

articles

Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors

DK Sarkar, PE Gottschall, and J Meites

Old female rats with spontaneous prolactin-secreting pituitary tumors (prolactinomas) and young females with prolactinomas produced by prolonged estrogen treatment had damaged tuberoinfundibular dopaminergic neurons. Since these neurons inhibit the function of pituitary prolactin-secreting cells, their destruction may lead to development of prolactinomas.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Changes in thrombospondin-1 levels in the endothelial cells of the anterior pituitary during estrogen-induced prolactin-secreting pituitary tumors.
A. J Sarkar, K. Chaturvedi, C. P. Chen, and D. K Sarkar (2007)
J. Endocrinol. 192, 395-403
   Abstract »    Full Text »    PDF »
Dopamine, Dopamine D2 Receptor Short Isoform, Transforming Growth Factor (TGF)-{beta}1, and TGF-{beta} Type II Receptor Interact to Inhibit the Growth of Pituitary Lactotropes.
D. K. Sarkar, K. Chaturvedi, S. Oomizu, N. I. Boyadjieva, and C. P. Chen (2005)
Endocrinology 146, 4179-4188
   Abstract »    Full Text »    PDF »
Folliculostellate Cells Determine the Susceptibility of Lactotropes to Estradiol's Mitogenic Action.
S. Oomizu, K. Chaturvedi, and D. K. Sarkar (2004)
Endocrinology 145, 1473-1480
   Abstract »    Full Text »    PDF »
Autocrine/Paracrine Action of Pituitary Vasoactive Intestinal Peptide on Lactotroph Hyperplasia Induced by Estrogen.
O. Gomez and J. A. Balsa (2003)
Endocrinology 144, 4403-4409
   Abstract »    Full Text »    PDF »
Targeted Overexpression of Luteinizing Hormone Causes Ovary-Dependent Functional Adenomas Restricted to Cells of the Pit-1 Lineage.
H. P. Mohammad, R. A. Abbud, A. F. Parlow, J. S. Lewin, and J. H. Nilson (2003)
Endocrinology 144, 4626-4636
   Abstract »    Full Text »    PDF »
The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague--Dawley Rats.
S. Molon-Noblot, P. Laroque, J. B. Coleman, C.-M. Hoe, and K. P. Keenan (2003)
Toxicol Pathol 31, 310-320
   Abstract »    PDF »
Transforming Growth Factor-{beta}3 Stimulates Lactotrope Cell Growth by Increasing Basic Fibroblast Growth Factor from Folliculo-Stellate Cells.
S. Hentges, N. Boyadjieva, and D. K. Sarkar (2000)
Endocrinology 141, 859-867
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein Kinase-Dependent Stimulation of Proliferation of Rat Lactotrophs in Culture by 3',5'-Cyclic Adenosine Monophosphate.
S. Suzuki, I. Yamamoto, and J. Arita (1999)
Endocrinology 140, 2850-2858
   Abstract »    Full Text »
Angiotensin II-induced Ca2+ mobilization and prolactin release in normal and hyperplastic pituitary cells.
G. Diaz-Torga, A. G. Iglesias, R. Achaval-Zaia, C. Libertun, and D. Becu-Villalobos (1998)
Am J Physiol Endocrinol Metab 274, E534-E540
   Abstract »    Full Text »    PDF »
Stimulatory Effect of Human, but not Bovine, Growth Hormone Expression on Numbers of Tuberoinfundibular Dopaminergic Neurons in Transgenic Mice.
C. J. Phelps and A. Bartke (1997)
Endocrinology 138, 2849-2855
   Abstract »    Full Text »    PDF »
Toxicokinetic and Mechanistic Considerations in the Interpretation of the Rodent Bioassay.
J. S. MacDonald, G. R. Lankas, and R. E. Morrissey (1994)
Toxicol Pathol 22, 124-140
   Abstract »    PDF »
Comparative Aspects of Contraceptive Steroids: Effects Observed In Rats.
R. F. McConnell (1989)
Toxicol Pathol 17, 385-388
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)