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Science 12 November 1982:
Vol. 218. no. 4573, pp. 646 - 652
DOI: 10.1126/science.6753149
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Articles

Science, Vol 218, Issue 4573, 646-652
Copyright © 1982 by American Association for the Advancement of Science

articles

Translational efficiency of transfer RNA's: uses of an extended anticodon

M Yarus

Transfer RNA's are probably very strongly selected for translational efficiency. In this article, the argument is presented that the coding performance of the triplet anticodon is enhanced by selection of a matching anticodon loop and stem sequence. the anticodon plus these nearby sequence features (the extended anticodon) therefore contains more coding information than the anticodon alone and can perform more efficiently and accurately at the ribosome. This idea successfully accounts for the relative efficiencies of many transfer RNA's.


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