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Science 5 November 1982:
Vol. 218. no. 4572, pp. 582 - 584
DOI: 10.1126/science.7123260
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Articles

Science, Vol 218, Issue 4572, 582-584
Copyright © 1982 by American Association for the Advancement of Science

articles

Intracellular recordings from cochlear outer hair cells

P Dallos, J Santos-Sacchi, and A Flock

Intracellular recordings were made from outer hair cells in the third turn of the guinea pig cochlea, and the electrical characteristics of the cells were compared to those of inner hair cells, supporting cells, and extracellular spaces from the same recording region. Outer hair cells have higher membrane potentials than do inner hair cells, but they produce smaller a-c receptor potentials. The frequency response characteristics of both types of hair cells are probably not significantly different. In the frequency region where tuning is optimal, both cell types produce depolarizing d-c receptor potentials, but outer hair cells also generate hyperpolarizing responses at low frequencies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cochlear Outer Hair Cell Motility.
J. Ashmore (2008)
Physiol Rev 88, 173-210
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Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier.
J. Gao, X. Wang, X. Wu, S. Aguinaga, K. Huynh, S. Jia, K. Matsuda, M. Patel, J. Zheng, M. Cheatham, et al. (2007)
PNAS 104, 12542-12547
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Mechanoelectric Transduction of Adult Inner Hair Cells.
S. Jia, P. Dallos, and D. Z. Z. He (2007)
J. Neurosci. 27, 1006-1014
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Cochlear function in Prestin knockout mice.
M. A Cheatham, K. H Huynh, J Gao, J Zuo, and P Dallos (2004)
J. Physiol. 560, 821-830
   Abstract »    Full Text »    PDF »
Stiffness of the Gerbil Basilar Membrane: Radial and Longitudinal Variations.
G. Emadi, C.-P. Richter, and P. Dallos (2004)
J Neurophysiol 91, 474-488
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Cl- flux through a non-selective, stretch-sensitive conductance influences the outer hair cell motor of the guinea-pig.
V. Rybalchenko and J. Santos-Sacchi (2003)
J. Physiol. 547, 873-891
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Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor protin.
J. Santos-Sacchi, W. Shen, J. Zheng, and P. Dallos (2001)
J. Physiol. 531, 661-666
   Abstract »    Full Text »    PDF »
Direct Visualization of Organ of Corti Kinematics in a Hemicochlea.
X. Hu, B. N. Evans, and P. Dallos (1999)
J Neurophysiol 82, 2798-2807
   Abstract »    Full Text »    PDF »
Somatic stiffness of cochlear outer hair cells is voltage-dependent.
D. Z. Z. He and P. Dallos (1999)
PNAS 96, 8223-8228
   Abstract »    Full Text »    PDF »
Effects of membrane potential on the voltage dependence of motility-related charge in outer hair cells of the guinea-pig.
J Santos-Sacchi, S Kakehata, and S Takahashi (1998)
J. Physiol. 510, 225-235
   Abstract »    Full Text »    PDF »
Acetylcholine, Outer Hair Cell Electromotility, and the Cochlear Amplifier.
P. Dallos, D. Z. Z. He, X. Lin, I. Sziklai, S. Mehta, and B. N. Evans (1997)
J. Neurosci. 17, 2212-2226
   Abstract »    Full Text »    PDF »


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