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Science 29 October 1982:
Vol. 218. no. 4571, pp. 477 - 478
DOI: 10.1126/science.6126931
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Articles

Science, Vol 218, Issue 4571, 477-478
Copyright © 1982 by American Association for the Advancement of Science

articles

Circulating somatostatin acts on the islets of Langerhans by way of a somatostatin-poor compartment

K Kawai, E Ipp, L Orci, A Perrelet, and RH Unger

Somatostatin perfused in canine pancreases at 10 to 20 picograms per milliliter or 10 to 20 percent of the pancreatic vein somatostatin concentration inhibited insulin and glucagon secretion. This suggests that the high local concentration of endogenous somatostatin is not in contact with somatostatin receptors of the islets. The integrity of this separation may determine the sensitivity of islet cells to circulating somatostatin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Diabetes 58, 299-301
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Somatostatin Secreted by Islet {delta}-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function.
A. C. Hauge-Evans, A. J. King, D. Carmignac, C. C. Richardson, I. C.A.F. Robinson, M. J. Low, M. R. Christie, S. J. Persaud, and P. M. Jones (2009)
Diabetes 58, 403-411
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{alpha}-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains.
J. Gromada, I. Franklin, and C. B. Wollheim (2007)
Endocr. Rev. 28, 84-116
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A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex.
J. H Koeslag, P. T Saunders, and E. Terblanche (2003)
J. Physiol. 549, 333-346
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Intra-Islet Somatostatin Regulates Glucagon Release via Type 2 Somatostatin Receptors in Rats.
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Diabetes 52, 1176-1181
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Gliclazide Directly Inhibits Arginine-Induced Glucagon Release.
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Assessment of the Role of Interstitial Glucagon in the Acute Glucose Secretory Responsiveness of In Situ Pancreatic {beta}-Cells.
K. Moens, V. Berger, J.-M. Ahn, C. Van Schravendijk, V. J. Hruby, D. Pipeleers, and F. Schuit (2002)
Diabetes 51, 669-675
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