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Science 22 October 1982:
Vol. 218. no. 4570, pp. 377 - 379
DOI: 10.1126/science.6289439
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Articles

Science, Vol 218, Issue 4570, 377-379
Copyright © 1982 by American Association for the Advancement of Science

articles

Inhibition of adrenocorticotropic hormone secretion in the rat by immunoneutralization of corticotropin-releasing factor

C Rivier, J Rivier, and W Vale

Intravenous administration of rabbit antiserum to ovine corticotropin-releasing factor (CRF) markedly reduced the CRF-induced rise of plasma adrenocorticotropic hormone (ACTH) in intact nonstressed adult male rats while blocking more than 75 percent of the ACTH release observed in rats exposed to ether stress. Furthermore, antiserum to CRF significantly lowered ACTH levels in adrenalectomized animals. These results suggest that endogenous CRF plays a physiological role in regulating ACTH secretion.


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Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor.
Y Tache, Y Goto, M. Gunion, W Vale, J River, and M Brown (1983)
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