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Science 22 October 1982:
Vol. 218. no. 4570, pp. 375 - 377
DOI: 10.1126/science.6289438
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Articles

Science, Vol 218, Issue 4570, 375-377
Copyright © 1982 by American Association for the Advancement of Science

articles

Hormonal regulation of gonadotropin receptors and steroidogenesis in cultured fetal rat tests

DW Warren, ML Dufau, and KJ Catt

Gonadotropic activation of the adult rat testis in vitro and in vivo is followed by down-regulation of luteinizing hormone receptors and decreased androgen responses to subsequent hormonal stimulation. In contrast, treatment of cultured fetal testes with gonadotropins and dibutyryl adenosine 3',5'-monophosphate enhanced steroidogenic responsiveness and did not cause the luteinizing hormone-receptor loss and desensitization that is characteristic of the adult gonad. The analysis of gonadotropin receptors and action in cultured fetal testis cells facilitates developmental studies of gonadal function, and has revealed significant differences in the responses of fetal and adult Leydig cells to gonadotropic regulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Estrogen-dependent Leydig cell protein recognized by monoclonal antibody to MCF-7 cell line.
D. Ciocca and M. Dufau (1984)
Science 226, 445-446
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