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Science 15 October 1982:
Vol. 218. no. 4569, pp. 291 - 293
DOI: 10.1126/science.7123235
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Articles

Science, Vol 218, Issue 4569, 291-293
Copyright © 1982 by American Association for the Advancement of Science

articles

Hemoglobin Parchman: double crossover within a single human gene

JG Adams 3rd, WT Morrison, and MH Steinberg

Structural analysis of a new variant hemoglobin revealed tryptic peptides with the amino acid composition of normal delta-globin, except for two internal peptides, which had the compositions of normal beta-globin. The most likely explanation for these findings is that a double, nonhomologous crossover between the delta-and beta-globin genes had occurred.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Unusual Rearrangement of the {alpha}-Globin Gene Cluster Containing Both the -{alpha}3.7 and {alpha}{alpha}{alpha}anti-4.2 Crossover Junctions: Clinical Diagnostic Implications and Possible Mechanisms.
W. Wang, A. Y.Y. Chan, L.-C. Chan, E. S.K. Ma, and S. S. Chong (2005)
Clin. Chem. 51, 2167-2170
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