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Science 15 October 1982:
Vol. 218. no. 4569, pp. 288 - 289
DOI: 10.1126/science.6750791
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Articles

Science, Vol 218, Issue 4569, 288-289
Copyright © 1982 by American Association for the Advancement of Science

articles

Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi

EE Montamat, C Burgos, NM Gerez de Burgos, LE Rovai, A Blanco, and EL Segura

Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide-linked enzymes (alpha-hydroxyacid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol.
A. Perez, P. Ojeda, X. Valenzuela, M. Ortega, C. Sanchez, L. Ojeda, M. Castro, J. G. Carcamo, M. C. Rauch, I. I. Concha, et al. (2009)
Am J Physiol Cell Physiol 297, C86-C93
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