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Science 8 October 1982:
Vol. 218. no. 4568, pp. 153 - 156
DOI: 10.1126/science.6289432
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Articles

Science, Vol 218, Issue 4568, 153-156
Copyright © 1982 by American Association for the Advancement of Science

articles

Are ions involved in the gating of calcium channels?

Y Saimi and C Kung

The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current activation, surface charge effects, or incomplete space clamping. The findings indicate participation of the divalent cations in the voltage-driven calcium channel gating process.


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