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Science 24 September 1982:
Vol. 217. no. 4566, pp. 1255 - 1256
DOI: 10.1126/science.6810465
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Articles

Science, Vol 217, Issue 4566, 1255-1256
Copyright © 1982 by American Association for the Advancement of Science

articles

Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid

MW Musch, RJ Miller, M Field and MI Siegel

Both 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) increased the short-circuit current (Isc) in rabbit colonic mucosa mounted in vitro in Ussing chambers. Measurements of chlorine-36 fluxes indicated that the Isc response to 5-HPETE is due to stimulation of active chlorine secretion. 9-, 11-, and 12-HPETE's and leukotrienes C4 and B4 produced either very small increases in Isc or no increase. In contrast to results in rabbit colon, no HPETE, HETE, or leukotriene was effective in rabbit ileal mucosa. The effects of 5-HPETE in the rabbit colon were unaffected by mepacrine, but could be partially blocked by indomethacin. These results suggest that drugs which block both cyclooxygenase and lipoxygenase may be effective antidiarrheals in patients with colitis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
International Union of Pharmacology XLIV. Nomenclature for the Oxoeicosanoid Receptor.
C. Brink, S.-E. Dahlen, J. Drazen, J. F. Evans, D. W. P. Hay, G. E. Rovati, C. N. Serhan, T. Shimizu, and T. Yokomizo (2004)
Pharmacol. Rev. 56, 149-157
   Abstract »    Full Text »    PDF »
Effect of Hydroxyeicosatetraenoic Acids on Furosemide-Sensitive Chloride Secretion in Rat Distal Colon.
M. Wegmann, A. Kämpen, S. Weber, H. W. Seyberth, and A. Köckerling (2000)
J. Pharmacol. Exp. Ther. 295, 133-138
   Abstract »    Full Text »
Do eicosanoids cause colonic dysfunction in experimental E coli 0157:H7 (EHEC) infection?.
C J Bell, E J Elliott, J L Wallace, D M Redmond, J Payne, Z Li, and E V O'Loughlin (2000)
Gut 46, 806-812
   Abstract »    Full Text »    PDF »
5-Oxo-6,8,11,14-eicosatetraenoic Acid Stimulates Isotonic Volume Reduction of Guinea Pig Jejunal Crypt Epithelial Cells.
R. J. MacLeod, P. Lembessis, J. R. Hamilton, and W. S. Powell (1999)
J. Pharmacol. Exp. Ther. 291, 511-516
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