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Science 24 September 1982:
Vol. 217. no. 4566, pp. 1250 - 1252
DOI: 10.1126/science.6896768
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Articles

Science, Vol 217, Issue 4566, 1250-1252
Copyright © 1982 by American Association for the Advancement of Science

articles

Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model

GS Drummond and A Kappas

The substantial increases of hepatic, splenic, and renal heme oxygenase levels that occur shortly after birth in neonatal rats were prevented by a single administration of tin-protoporphyrin (10 micromoles per kilogram of body weight). With this treatment serum bilirubin levels declined within 24 hours to near-normal adult levels and remained low throughout the postnatal period. Zinc-protoporphyrin at doses up to 50-fold greater than the effective dose of tin-protoporphyrin did not prevent the immediate increases in tissue heme oxygenase activities and in serum bilirubin levels that occur postnatally. Studies in vitro with microsomal heme oxygenase in human spleen indicate that tin-protoporphyrin is a potent competitive inhibitor of the oxidation of heme to bile pigment in this tissue.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. Tongers, J.-M. Knapp, M. Korf, T. Kempf, A. Limbourg, F. P. Limbourg, Z. Li, D. Fraccarollo, J. Bauersachs, X. Han, et al. (2008)
Cardiovasc Res 78, 294-300
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Pharmacological and Clinical Aspects of Heme Oxygenase.
N. G. Abraham and A. Kappas (2008)
Pharmacol. Rev. 60, 79-127
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Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes.
A. Uc, K. J. Reszka, G. R. Buettner, and J. B. Stokes (2007)
Am J Physiol Cell Physiol 292, C1906-C1914
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Motexafin Gadolinium-Induced Cell Death Correlates with Heme oxygenase-1 Expression and Inhibition of P450 Reductase-Dependent Activities.
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S. W. Ryter, J. Alam, and A. M. K. Choi (2006)
Physiol Rev 86, 583-650
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Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats.
D Sacerdoti, B Escalante, N. Abraham, J. McGiff, R. Levere, and M. Schwartzman (1989)
Science 243, 388-390
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Suppression of Carbon Monoxide Excretion Rate by Tin Protoporphyrin.
A. M. Posselt, L. K. Kwong, H. J. Vreman, and D. K. Stevenson (1986)
Arch Pediatr Adolesc Med 140, 147-150
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Implications for Risk Assessment of Host Factors Causing Large Pharmacokinetic Variations.
E. S. Vesell (1985)
Toxicology and Industrial Health 1, 135-152
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